Results 281 to 290 of about 9,751,730 (314)
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Molecular Biology, 2012
Transcription factor RUNX1 is one of the key regulatory proteins in vertebrates. It controls hematopoiesis and angiogenesis. It is indispensable during embryogenesis for the emergence of sites of definitive hematopoiesis and later in mature organisms for bone marrow blood stem cells differentiation.
E N, Markova +3 more
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Transcription factor RUNX1 is one of the key regulatory proteins in vertebrates. It controls hematopoiesis and angiogenesis. It is indispensable during embryogenesis for the emergence of sites of definitive hematopoiesis and later in mature organisms for bone marrow blood stem cells differentiation.
E N, Markova +3 more
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Transcription factors on the move
Trends in Genetics, 2001We think of transcription factors as being confined to the cell where they are transcribed, but recent work shows they are able to move from cell to cell in plants. Plant cells are thought to communicate through membrane-lined channels called plasmodesmata.
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Transcription factors: An overview
The International Journal of Biochemistry & Cell Biology, 1997This special issue of the International Journal of Biochemistry and Cell Biology contains a series of review articles and original papers dealing with the topic of transcription factors. The purpose of this introductory article is to provide an overview of these factors, their mechanism of action, their regulation and the manner in which alterations in
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2006
POU domain transcription factor proteins are critical regulators of many developmental processes during embryogenesis, are prominent in the neural system where they are identified as BRN transcription factors, and can be reactivated during malignant transformation of cancerous tissue. This family of genes is characterized by a common 150-160 amino acid
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POU domain transcription factor proteins are critical regulators of many developmental processes during embryogenesis, are prominent in the neural system where they are identified as BRN transcription factors, and can be reactivated during malignant transformation of cancerous tissue. This family of genes is characterized by a common 150-160 amino acid
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Trends in Plant Science, 2010
WRKY transcription factors are one of the largest families of transcriptional regulators in plants and form integral parts of signalling webs that modulate many plant processes. Here, we review recent significant progress in WRKY transcription factor research. New findings illustrate that WRKY proteins often act as repressors as well as activators, and
Rushton, P. +3 more
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WRKY transcription factors are one of the largest families of transcriptional regulators in plants and form integral parts of signalling webs that modulate many plant processes. Here, we review recent significant progress in WRKY transcription factor research. New findings illustrate that WRKY proteins often act as repressors as well as activators, and
Rushton, P. +3 more
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Transcription factors on the move
Current Opinion in Plant Biology, 2012Mobile transcription factors play essential roles in plant development including the control of cell identity and tissue patterning, as well as organ initiation and the induction of major developmental switches. Within the past few years, the molecules and cellular structures that regulate the movement of these signals have emerged.
Shuang, Wu, Kimberly L, Gallagher
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Transcription factors in disease
Current Opinion in Genetics & Development, 1996Mutations affecting several predominantly tissue-specific transcriptional regulators have recently been associated with disease phenotypes. Although the mutational spectrum is variable, many of the reported cases involve clear loss-of-function mutations-such as Waardenburg syndrome type 1, aniridia and Rubinstein-Taybi syndrome-suggesting that the ...
D, Engelkamp, V, van Heyningen
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Transcription factors in hematopoiesis
Current Opinion in Genetics & Development, 1999The advent of gene targeting in the mouse has led to rapid advances in the identification of factors controlling gene expression that are essential for normal hematopoietic development. Recent work has also uncovered roles for some of these factors in leukemogenesis and in the global regulation of chromatin structure.
I, Engel, C, Murre
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Eukaryotic transcription factors
Current Opinion in Structural Biology, 2002Recently determined high-resolution structures of eukaryotic transcription factors have illuminated the enzymatic mechanism underlying transcription. Progress has been made in characterising protein-protein interactions between negative cofactors and general transcription factors, and between transrepression domains and corepressors.
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Inhibitory transcription factors
The International Journal of Biochemistry & Cell Biology, 1996Although the majority of the transcription factors that were initially characterized had a stimulatory effect on gene expression, it is now clear that transcription factors that inhibit gene transcription are at least as important in regulating a wide variety of processes, including development.
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