Results 101 to 110 of about 2,492,980 (260)

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Transcriptional activation: risky business [PDF]

, 2001
Transcriptional regulation is all about getting RNA polymerase to the right place on the gene at the right time and making sure that it is competent to conduct transcription.
Tansey, W. P.
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Transient-mediated fate determination in a transcriptional circuit of HIV [PDF]

, 2007
Steady-state behavior and bistability have been proposed as mechanisms for decision-making in gene circuits. However, transient gene expression has also been proposed to control cell fate with the decision arbitrated by the lifetime of the expression ...
Michael Simpson, Roy D. Dar, Leor Weinberger   +2 more
core  

Genome-wide transcriptional profiling of peripheral blood leukocytes from cattle infected with Mycobacterium bovis reveals suppression of host immune genes [PDF]

, 2011
Background Mycobacterium bovis is the causative agent of bovine tuberculosis (BTB), a pathological infection with significant economic impact.
Magee, David A, Gordon, Stephen V, Martin Irene, Stephen DE Park, Karsten Hokamp, Stephen V Gordon, Gordon Stephen V, Killick Kate E, Magee David A, Park Stephen DE, Martin, Irene, Irene Martin, Killick, Kate E, John A Browne, MacHugh, David E, MacHugh David E, Kate E Killick, David E MacHugh, Gormley, Eamonn, Park, Stephen D. E., Hokamp, Karsten, Kieran G Meade, Eamonn Gormley, Gormley Eamonn, David A Magee, Hokamp Karsten, Browne John A, Browne, John A, Meade, Kieran G, Cliona O'Farrelly, O'Farrelly, Cliona, Meade Kieran G, O'Farrelly Cliona   +32 more
core   +2 more sources

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Over-expression of a chimeric gene of the transcriptional co-activator MBF1 fused to the EAR repressor motif causes developmental alteration in Arabidopsis and tomato [PDF]

, 2008
Transcriptional co-activators of the Multiprotein Bridging Factor1 (MBF1) type belong to a multigenic family that encode key components of the machinery controlling gene expression by communicating between transcription factors and the basal ...
Regad, Farid, Latché, Alain, Hommel, Marie, Khalil Ahmad, Qaiser, Pech, Jean-Claude, Jaimes Miranda, Fabiola, Pouzet, Cécile, Mila, Isabelle, Bouzayen, Mondher   +8 more
core   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Transcriptional regulation mediated through the conjugation and deconjugation of the small ubiquitin-like modifiers SUMO-1, SUMO-2, and SUMO-3 [PDF]

, 2012
SUMO-1/2/3 are members of the ubiquitin-like family of protein modifiers. These proteins are covalently attached to numerous proteins in a directed and controlled manner.
Girdwood, David William Haxton
core   +2 more sources

The ansamycin antibiotic, rifamycin SV, inhibits BCL6 transcriptional repression and forms a complex with the BCL6-BTB/POZ domain [PDF]

, 2014
BCL6 is a transcriptional repressor that is over-expressed due to chromosomal translocations, or other abnormalities, in ~40% of diffuse large B-cell lymphoma.
Simon D. Wagner (530388), Jamieson, Andrew G, Louise Fairall, Simon D Wagner, Wagner, Simon D, Jamieson Andrew G., Schwabe John W. R., Ko Ferrigno Paul, John W. R. Schwabe (7604093), Paul Ko Ferrigno (41085), Goult, Benjamin T., Wagner, SD, Benjamin T Goult, Evans, SE, Ford, Robert, Sian E Evans, Schwabe, JWR, Andrew G Jamieson, Fairall, Louise, Andrew G. Jamieson (530386), Wagner, Simon D., Benjamin T. Goult (173495), Sian E. Evans (7622282), Ko Ferrigno, Paul, Evans, Sian E, Robert Ford (89276), Ford Robert, Schwabe, John W R, Goult Benjamin T., P. Ko Ferrigno (7674905), Evans Sian E., Fairall, L, Fairall Louise, Schwabe, John W.R., Simon D. Wagner (7633943), John W R Schwabe, Evans, Sian E., Goult, Benjamin T, Goult, BT, Robert Ford, Jamieson, Andrew G., Louise Fairall (530385), Ko Ferrigno, P, Ford, R, John W. R. Schwabe (530387), Jamieson, AG, Wagner Simon D., Sian E. Evans (530384), Paul Ko Ferrigno, R. Ford (7674908)   +49 more
core   +1 more source