Results 151 to 160 of about 3,231,478 (258)

Molecular and transcriptional regulation of plant defense responses to aphid infestation. [PDF]

Stress Biol
Patil V, Rehsawla R, Barman AK.
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Author Correction: Ontogeny and transcriptional regulation of Thetis cells. [PDF]

Nature
Paucar Iza YA, Park T, Baker E, Shibu G, Hoelting T, Feather G, Yadav A, Parisotto YF, Zhao Z, Akagbosu B, Bayes ME, Fisher L, James LM, Ma J, Philpot BD, Afzali B, Leslie C, Brown CC.   +17 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Transcriptional regulation of disease-relevant microglial activation programs. [PDF]

Neuron
McQuade A, Mishra R, Hagan V, Liang W, Colias PJ, Castillo VC, Gonzalez B, Lubin JP, Haage V, Marshe V, Fujita M, Ta T, Gomes L, Teter O, Han X, Robichaud N, Chasins SE, Rexach JE, De Jager PL, Nuñez JK, Kampmann M.   +20 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Orchard and storage-dependent metabolic and transcriptional regulation of superficial scald in 'Packham's Triumph' pears. [PDF]

Front Plant Sci
Lwin HP, Yoo J, Zhang H, Hargarten H, Honaas L, Rudell DR, Defilippi BG, Mejía N, Torres CA.   +8 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Hierarchical interplay between H3K27ac and H3K4me3 in transcriptional regulation. [PDF]

Nat Commun
Zhou C, Dong C, Zhao W, Liang FS.
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source