Results 221 to 230 of about 4,769,934 (397)

Post-transcriptional Regulation

Gene Control, 2020
D. Latchman
semanticscholar   +1 more source

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

Transcriptional regulation and signaling of type IV interferon in Carassius gibelio. [PDF]

Cell Commun Signal
Dai C, Zhu Y, Qian S, Fan Y, Weng Z, Li L, Wang J, Yuan J.   +7 more
europepmc   +1 more source

Transcriptional Regulation of the Warburg Effect in Cancer by SIX1.

Cancer Cell, 2018
Ling Li, Yingchun Liang, L. Kang, Yang Liu, Shan Gao, Siyu Chen, Y. Li, W. You, Qian Dong, T. Hong, Zhifeng Yan, Shuai Jin, Tao Wang, Wei Zhao, H. Mai, Jun Huang, Xiao-Wei Han, Q. Ji, Q. Song, Chao Yang, Shixin Zhao, Xiaojie Xu, Q. Ye   +22 more
semanticscholar   +1 more source

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

Molecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan, Moshe Leitner, Amos Toren, Shoshana Paglin, Michal Yalon   +4 more
wiley   +1 more source

Small modifier, big decision: switching to SUMO mode adds weight to cancer stemness in mammary tumors

Molecular Oncology, EarlyView.
Inhibition of protein SUMOylation has been shown to block tumorigenesis; however, the specific mechanisms by which SUMOylation controls the tumor‐initiating capacities remain elusive. Li et al. describe the role of Etv1 SUMOylation in cancer stem cells using mouse models of mammary gland tumorigenesis.
Veronika Yevdokimova, Yannick D. Benoit
wiley   +1 more source

Induction of macrophage Ia antigen expression by rIFN-gamma and down-regulation by IFN-alpha/beta and dexamethasone are regulated transcriptionally. [PDF]

, 1988
D Fertsch-Ruggio, Daniel R. Schoenberg, Stefanie N. Vogel   +2 more
openalex   +1 more source

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

Molecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella, Giuseppina Comito, Luigi Ippolito, Erica Pranzini, Marta Iozzo, Giulia Gangarossa, Francesca Virgilio, Silvia Bua, Alessio Nocentini, Giada Sandrini, Nicla Lorito, Marina Bacci, Gabriella Nesi, Pietro Spatafora, Sergio Serni, Claudiu T. Supuran, Andrea Morandi, Paola Chiarugi, Elisa Giannoni   +18 more
wiley   +1 more source

Editorial: Come as you R(NA): post-transcriptional regulation will do the rest. [PDF]

Front Mol Neurosci
Mauger O, Kiebler MA, Bernard C.
europepmc   +1 more source

Transcriptional Regulation of Carnitine Palmitoyltransferase Synthesis in Riboflavin Deficiency in Rats

, 1988
Paul S. Brady, Ya-Xiong Feng, Linda J. Brady   +2 more
openalex   +1 more source