Results 131 to 140 of about 8,622 (220)
A noncanonical role for Jagged1 in endothelial mechanotransduction
The FEBS Journal, EarlyView.This study reveals a noncanonical role for Jagged1 in endothelial mechanotransduction. Shear stress modulates Jagged1 expression and subcellular localization. Loss of Jagged1 attenuates mechanotransduction and reduces Src, VEGFR2, and ERK signaling. Direct mechanical stimulation of Jagged1 induces activation of these signaling pathways.
Freddy Suarez Rodriguez +7 more
wiley +1 more source
The FEBS Journal, EarlyView.The role of PARs in platelet function is fairly known; however, the underlying mechanisms are not fully understood. We report that thrombin myristoylates PAR4 in mouse platelets and PAR1 and PAR4 in human platelets, facilitating their membrane transport and interaction, leading to PAR3/4 heterodimers in mice and PAR1/4 heterodimers in humans.
Suresh Govatati +4 more
wiley +1 more source
The FEBS Journal, EarlyView.We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti +11 more
wiley +1 more source
ROBERT WALSER'S ‘BLEISTIFTWEG’: POETICS OF ATTENTION AS CRAFT
German Life and Letters, EarlyView.ABSTRACT This article examines Robert Walser's entry into what he called his ‘Bleistiftgebiet’ in the early 1920s, when in response to a profound crisis as a writer he began to produce manuscripts in minuscule size, the so‐called ‘Mikrogramme’ (microscripts). Intertwining the analysis of the short prose form with Walser's reflections on the short‐lived
Anne Fuchs
wiley +1 more source
International Journal of Applied Linguistics, EarlyView.ABSTRACT This study examines multilingual practices in research interviews, focusing on English lexical insertions in Chinese‐language research interviews with teachers of Chinese in Australian secondary schools, and treating these code‐switches as analytically meaningful rather than incidental.
Chengwen Yuan, Tianwei Zhang, Gary Bonar
wiley +1 more source
Culturally and Linguistically Diverse Fathers' Experiences of Early Parenting: A Qualitative Study
Journal of Advanced Nursing, EarlyView.ABSTRACT Aim This study aimed to explore culturally and linguistically diverse (CALD) fathers' early parenting support needs in the perinatal period in Australia. Design A qualitative descriptive research study. Participant fathers were recruited using purposive and snowball sampling who self‐identified as CALD. Methods Data were collected through semi‐
Rakime Elmir +5 more
wiley +1 more source
Cyclin‐dependent kinase 13 is indispensable for normal mouse heart development
Journal of Anatomy, Volume 246, Issue 4, Page 616-630, April 2025.Congenital heart disease (CHD) is the most common defect in live births. The role of cyclin‐dependent kinase (CDK13) in cardiogenesis and CHD was studied using a transgenic mouse model (Cdk13tm1b) carrying deletion of exons 3 and 4, causing loss of function.
Qazi Waheed‐Ullah +8 more
wiley +1 more source
Literary Journalism on Trial: Janet Malcolm, Criminal Character and the Legacy of New Journalism
Critical Quarterly, EarlyView.
Jess Cotton
wiley +1 more source
(Re)Defining language pedagogy activity: A sociomaterialist perspective
The Modern Language Journal, EarlyView.Abstract Language pedagogy activity (LPA) is central to the functioning of language classrooms worldwide, and this article (re)defines LPA. While prevailing applied linguistics conceptualizations of “activity” are often theoretical and anthropocentric, our definition of LPA is empirically supported and foregrounds material agency.
Anne Marie Guerrettaz +3 more
wiley +1 more source