Nonlinearity in genetic decoding: Homologous DNA replicase genes use alternatives of transcriptional slippage or translational frameshifting [PDF]
Proceedings of the National Academy of Sciences, 2000 The τ and γ subunits of DNA polymerase III are both encoded by a single gene in Escherichia coli and Thermus thermophilus . γ is two-thirds the size of τ and shares virtually all its amino acid sequence with τ. E. coli and T.
B, Larsen +4 more
openaire +2 more sources
Genome-Wide Spectra of Transcription Insertions and Deletions Reveal That Slippage Depends on RNA:DNA Hybrid Complementarity [PDF]
mBio, 2017 ABSTRACT Advances in sequencing technologies have enabled direct quantification of genome-wide errors that occur during RNA transcription. These errors occur at rates that are orders of magnitude higher than rates during DNA replication, but due to technical difficulties such measurements have been limited to single-base ...
Charles C. Traverse, Howard Ochman
openaire +3 more sources
Transcription of satellite DNAs in insects [PDF]
, 2011 Chromatin condensation is an important regulatory mechanism of gene silencing as well as gene activation for the hundreds of functional protein genes harbored in heterochromatic regions of different insect species.
D. Ugarkovic +3 more
core +1 more source
Analysis of De Novo HOXA 13 Polyalanine Expansions Supports Replication Slippage Without Repair in Their Generation [PDF]
, 2013 Polyalanine repeat expansion diseases are hypothesized to result from unequal chromosomal recombination, yet mechanistic studies are lacking. We identified two de novo cases of hand‐foot‐genital syndrome (HFGS) associated with polyalanine expansions in ...
Innis, Jeffrey W. +8 more
core +1 more source
Isolation and Characterization of RNA Polymerase rpoB Mutations That Alter Transcription Slippage during Elongation in Escherichia coli [PDF]
Journal of Biological Chemistry, 2013 Transcription fidelity is critical for maintaining the accurate flow of genetic information. The study of transcription fidelity has been limited because the intrinsic error rate of transcription is obscured by the higher error rate of translation, making identification of phenotypes associated with transcription infidelity challenging.
Yan Ning, Zhou +8 more
openaire +2 more sources
Dissecting the role of low-complexity regions in the evolution of vertebrate proteins
BMC Evolutionary Biology, 2012 Background Low-complexity regions (LCRs) in proteins are tracts that are highly enriched in one or a few amino acids. Given their high abundance, and their capacity to expand in relatively short periods of time through replication slippage, they can ...
Radó-Trilla Núria, Albà MMar
doaj +1 more source
Demonstration of the Presence of the "Deleted" MIR122 Gene in HepG2 Cells [PDF]
, 2015 MicroRNA 122 (miR-122) is highly expressed in the liver where it influences diverse biological processes and pathways, including hepatitis C virus replication and metabolism of iron and cholesterol.
Fei, Y +8 more
core +1 more source
Transcriptional slippage occurs during elongation at runs of adenine or thymine inEscherichia coli
Nucleic Acids Research, 1990 A run of 11 adenine or thymine residues at the 5' end of an out-of ...
L A, Wagner +4 more
openaire +3 more sources
Advanced Healthcare Materials, EarlyView.To dissect how mechanical forces influence intestinal physiology, we developed a stretchable 3D colon‐on‐chip that integrates tunable topography, stiffness and peristalsis‐like motion within a physiologically relevant microenvironment. We showed that stretching is a dominant factor governing epithelial behavior, markedly enhancing proliferation and ...
Moencopi Bernheim‐Dennery +10 more
wiley +1 more source
Biologically motivated asymmetric exclusion process: Interplay of congestion in RNA polymerase traffic and slippage of nascent transcript [PDF]
Physical Review E, 2019 We develope a theoretical framework, based on exclusion process, that is motivated by a biological phenomenon called transcript slippage (TS). In this model a discrete lattice represents a DNA strand while each of the particles that hop on it unidirectionally, from site to site, represents a RNA polymerase (RNAP).
Ghosh, Soumendu +5 more
openaire +3 more sources