Results 31 to 40 of about 8,622 (220)

A Genome-Wide Analysis of Genetic Diversity inTrypanosoma cruzi Intergenic Regions [PDF]

, 2014
Background Trypanosoma cruzi is the causal agent of Chagas Disease. Recently, the genomes of representative strains from two major evolutionary lineages were sequenced, allowing the construction of a detailed genetic diversity map for this important ...
Agüero, Fernan Gonzalo, Panunzi, Leonardo Gabriel   +1 more
core   +3 more sources

Transcriptional slippage controls production of type III secretion apparatus components in Shigella flexneri [PDF]

Molecular Microbiology, 2006
SummaryDuring transcription, series of approximately 9 As or Ts can direct RNA polymerase to incorporate into the mRNA nucleotides not encoded by the DNA, changing the reading frame downstream from the slippage site. We detected series of 9 or 10 As in spa13, spa33 and mxiA encoding type III secretion apparatus components.
Penno, Christophe, Hachani, Abderrahman, Biskri, Latefa, Sansonetti, Philippe, Allaoui, Abdelmounaaim, Parsot, Claude   +5 more
openaire   +2 more sources

Mitotic Stress Is an Integral Part of the Oncogene-Induced Senescence Program that Promotes Multinucleation and Cell Cycle Arrest

Cell Reports, 2015
Oncogene-induced senescence (OIS) is a tumor suppression mechanism that blocks cell proliferation in response to oncogenic signaling. OIS is frequently accompanied by multinucleation; however, the origin of this is unknown.
Dina Dikovskaya, John J. Cole, Susan M. Mason, Colin Nixon, Saadia A. Karim, Lynn McGarry, William Clark, Rachael N. Hewitt, Morgan A. Sammons, Jiajun Zhu, Dimitris Athineos, Joshua D.G. Leach, Francesco Marchesi, John van Tuyn, Stephen W. Tait, Claire Brock, Jennifer P. Morton, Hong Wu, Shelley L. Berger, Karen Blyth, Peter D. Adams   +20 more
doaj   +1 more source

Transcription as a Threat to Genome Integrity [PDF]

, 2016
Genomes undergo different types of sporadic alterations, including DNA damage, point mutations, and genome rearrangements, that constitute the basis for evolution.
Aguilera López, Andrés, Gaillard, Hélène   +1 more
core   +1 more source

Non-programmed transcriptional frameshifting is common and highly RNA polymerase type-dependent

Microbial Cell Factories, 2018
Background The viral or host systems for a gene expression assume repeatability of the process and high quality of the protein product. Since level and fidelity of transcription primarily determines the overall efficiency, all factors contributing to ...
Dawid Koscielniak, Ewa Wons, Karolina Wilkowska, Marian Sektas   +3 more
doaj   +1 more source

The Yeast Transcription Terminator for RNA Polymerase I Is Designed to Prevent Polymerase Slippage [PDF]

Journal of Biological Chemistry, 1996
A transcription terminator for RNA polymerase I (polI) in the yeast, Saccharomyces cerevisiae, is composed of two essential elements, the 11bp binding site for Reb1p and an upstream T-rich element coding for the last 10-12 nucleotides of the terminated transcript.
S W, Jeong, W H, Lang, R H, Reeder
openaire   +2 more sources

Possible formation of mitochondrial-RNA containing chimeric or trimeric RNA implies a post-transcriptional and post-splicing mechanism for RNA fusion. [PDF]

PLoS ONE, 2013
Human cells are known to express many chimeric RNAs, i.e. RNAs containing two genes' sequences. Wondering whether there also is trimeric RNA, i.e. an RNA containing three genes' sequences, we wrote simple computer code to screen human expression sequence
Wei Yang, Jian-min Wu, An-ding Bi, Yong-chang Ou-Yang, Hai-hong Shen, Gung-wei Chirn, Jian-hua Zhou, Emily Weiss, Emily Pauline Holman, D Joshua Liao   +9 more
doaj   +1 more source

Transcriptional slippage in bacteria: distribution in sequenced genomes and utilization in IS element gene expression. [PDF]

Genome Biol, 2005
Abstract Background Transcription slippage occurs on certain patterns of repeat mononucleotides, resulting in synthesis of a heterogeneous population of mRNAs. Individual mRNA molecules within this population differ in the number of nucleotides they contain that are not specified by the template.
Baranov PV, Hammer AW, Zhou J, Gesteland RF, Atkins JF.   +4 more
europepmc   +4 more sources

Active role of elongation factor G in maintaining the mRNA reading frame during translation. [PDF]

, 2019
During translation, the ribosome moves along the mRNA one codon at a time with the help of elongation factor G (EF-G). Spontaneous changes in the translational reading frame are extremely rare, yet how the precise triplet-wise step is maintained is not ...
Belardinelli, R., Bock, L., Grubmüller, H., Peng, B., Peske, F., Rodnina, M.   +5 more
core   +2 more sources

Structure in nascent RNA leads to termination of slippage transcription by T7 RNA polymerase [PDF]

Nucleic Acids Research, 2001
T7 RNA polymerase presents a very simple model system for the study of fundamental aspects of transcription. Some time ago it was observed that in the presence of only GTP as a substrate, on a template encoding the initial sequence GGGA., T7 RNA polymerase will synthesize a 'ladder' of poly-G RNA products.
Kuzmine, I, Gottlieb, PA, Martin, CT
openaire   +2 more sources