Results 21 to 30 of about 8,622 (220)

Mutational analysis of the Potyviridae transcriptional slippage site utilized for expression of the P3N-PIPO and P1N-PISPO proteins. [PDF]

Nucleic Acids Res, 2016
The Potyviridae comprise the largest and most important family of RNA plant viruses. An essential overlapping ORF, termed pipo, resides in an internal region of the main polyprotein ORF. Recently, expression of pipo was shown to depend on programmed transcriptional slippage at a conserved GAAAAAA sequence, resulting in the insertion of an extra A into ...
Olspert A, Carr JP, Firth AE.
europepmc   +5 more sources

Comparative Genome Analysis Reveals Accumulation of Single-Nucleotide Repeats in Pathogenic Escherichia Lineages

Current Issues in Molecular Biology, 2022
Homopolymeric tracts (HPTs) can lead to phase variation and DNA replication slippage, driving adaptation to environmental changes and evolution of genes and genomes.
Koji Ishiya, Nobutaka Nakashima
doaj   +1 more source

A Novel Transcriptional Slippage Mechanism Rescues Dystrophin Expression from a DMD Frameshift Variant. [PDF]

Ann Neurol
Pathogenic DMD variants usually follow the reading‐frame rule: out‐of‐frame changes cause Duchenne muscular dystrophy, whereas in‐frame ones produce Becker muscular dystrophy (BMD). We report a 23‐year‐old man with BMD‐like weakness, calf hypertrophy, elevated creatine kinase, and dilated ...
Naruse H, Mitsui J, Kubota A, Okubo S, Mitsuchi S, Sumi K, Tanifuji S, Komaki S, Kitamura A, Maeda M, Yashita D, Sudo A, Matsukawa T, Hamada M, Satake W, Tsuji S, Toda T.   +16 more
europepmc   +2 more sources

Single-Cell Mononucleotide Microsatellite Analysis Reveals Differential Insertion-Deletion Dynamics in Mouse T Cells

Frontiers in Genetics, 2022
Microsatellite sequences are particularly prone to slippage during DNA replication, forming insertion-deletion loops that, if left unrepaired, result in de novo mutations (expansions or contractions of the repeat array).
Elli-Mari Aska, Bulat Zagidullin, Bulat Zagidullin, Esa Pitkänen, Esa Pitkänen, Esa Pitkänen, Liisa Kauppi   +6 more
doaj   +1 more source

The mitochondrial genome of the venomous cone snail conus consors [PDF]

, 2012
Cone snails are venomous predatory marine neogastropods that belong to the species-rich superfamily of the Conoidea. So far, the mitochondrial genomes of two cone snail species (Conus textile and Conus borgesi) have been described, and these feed on ...
Baden-Tillson, Holly, Brauer, Age, Heidler, Juliana, Kauferstein, Silke, Kurz, Alexander, Mebs, Dietrich, Remm, Maido, Stockwell, Tim, Stöcklin, Reto, Wittig, Ilka   +9 more
core   +12 more sources

Correlated occurrence and bypass of frame-shifting insertion-deletions (InDels) to give functional proteins. [PDF]

PLoS Genetics, 2013
Short insertions and deletions (InDels) comprise an important part of the natural mutational repertoire. InDels are, however, highly deleterious, primarily because two-thirds result in frame-shifts.
Liat Rockah-Shmuel, Ágnes Tóth-Petróczy, Asaf Sela, Omri Wurtzel, Rotem Sorek, Dan S Tawfik   +5 more
doaj   +1 more source

Uncoupling of Mitosis and Cytokinesis Upon a Prolonged Arrest in Metaphase Is Influenced by Protein Phosphatases and Mitotic Transcription in Fission Yeast

Frontiers in Cell and Developmental Biology, 2022
Depletion of the Anaphase-Promoting Complex/Cyclosome (APC/C) activator Cdc20 arrests cells in metaphase with high levels of the mitotic cyclin (Cyclin B) and the Separase inhibitor Securin.
Nathalia Chica, Marina Portantier, Mari Nyquist-Andersen, Silvia Espada-Burriel, Sandra Lopez-Aviles, Sandra Lopez-Aviles   +5 more
doaj   +1 more source

Microsatellite repeat instability fuels evolution of embryonic enhancers in Hawaiian Drosophila. [PDF]

PLoS ONE, 2014
For ∼30 million years, the eggs of Hawaiian Drosophila were laid in ever-changing environments caused by high rates of island formation. The associated diversification of the size and developmental rate of the syncytial fly embryo would have altered ...
Andrew Brittain, Elizabeth Stroebele, Albert Erives   +2 more
doaj   +1 more source

Genome-wide characterization of microsatellite DNA in fishes: survey and analysis of their abundance and frequency in genome-specific regions

BMC Genomics, 2021
Background Microsatellite repeats are ubiquitous in organism genomes and play an important role in the chromatin organization, regulation of gene activity, recombination and DNA replication. Although microsatellite distribution patterns have been studied
Yi Lei, Yu Zhou, Megan Price, Zhaobin Song   +3 more
doaj   +1 more source

Semi-Supervised Pipeline for Autonomous Annotation of SARS-CoV-2 Genomes

Viruses, 2021
SARS-CoV-2 genomic sequencing efforts have scaled dramatically to address the current global pandemic and aid public health. However, autonomous genome annotation of SARS-CoV-2 genes, proteins, and domains is not readily accomplished by existing methods ...
Kristen L. Beck, Edward Seabolt, Akshay Agarwal, Gowri Nayar, Simone Bianco, Harsha Krishnareddy, Timothy A. Ngo, Mark Kunitomi, Vandana Mukherjee, James H. Kaufman   +9 more
doaj   +1 more source