Results 161 to 170 of about 6,140 (191)
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webTWAS 2.0: update platform for identifying complex disease susceptibility genes through transcriptome-wide association study

Nucleic Acids Research
Transcriptome-wide association study (TWAS) has successfully identified numerous complex disease susceptibility genes in the post-genome-wide association study (GWAS) era.
Chen Cao   +8 more
semanticscholar   +1 more source

Transcriptome-wide association study discovers functional long non-coding RNAs in coronary artery disease

European Heart Journal
Genetically regulated long non-coding RNAs (lncRNAs) in coronary artery disease (CAD) have not been investigated. To discover CAD-relevant lncRNAs, we performed the transcriptome-wide association study (TWAS) using a subset genomic data of ...
S. Li   +4 more
semanticscholar   +1 more source

A cross-tissue transcriptome-wide association study identified susceptibility genes for age-related macular degeneration

Scientific Reports
Age-related macular degeneration (AMD) is a complex multifactorial disease with a significant genetic component. Despite extensive research efforts, the underlying molecular mechanisms remain elusive, necessitating innovative approaches to identify ...
Hongfan Yang, Haofei Huang, Kunlin Pu
semanticscholar   +1 more source

A cross-tissue transcriptome-wide association study identifies new susceptibility genes for insomnia.

Journal of Neurophysiology
Background: Despite a significant genetic component to insomnia (heritability: 22-25%), the genetic loci that modulate insomnia risk remain limited. Methods: We employed the Unified Test for Molecular Markers (UTMOST) for transcriptome-wide association ...
Li Li   +6 more
semanticscholar   +1 more source

A cross-tissue transcriptome-wide association study reveals novel susceptibility genes for erectile dysfunction.

Andrology
BACKGROUND Erectile dysfunction (ED) is a common condition affecting millions of men worldwide. While genome-wide association studies (GWAS) have identified genetic loci associated with ED risk, the potential causative genes and their biological ...
Tianle Zhu   +8 more
semanticscholar   +1 more source

A cross-tissue transcriptome-wide association study identifies new susceptibility genes for benign prostatic hyperplasia

Scientific Reports
Benign prostatic hyperplasia (BPH) is a prevalent urinary system disorder. Despite evidence of a significant genetic component from previous studies, the specific pathogenic genes and biological mechanisms are still largely unknown.
Li Wang   +7 more
semanticscholar   +1 more source

Older adult participation in cancer clinical trials: A systematic review of barriers and interventions

Ca-A Cancer Journal for Clinicians, 2021
Mina S Sedrak   +2 more
exaly  

Intermittent fasting in the prevention and treatment of cancer

Ca-A Cancer Journal for Clinicians, 2021
Katherine Clifton   +2 more
exaly  

An overview of real‐world data sources for oncology and considerations for research

Ca-A Cancer Journal for Clinicians, 2022
Lynne Penberthy   +2 more
exaly  

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