Results 181 to 190 of about 8,166 (222)

Multivariate genome-wide analysis reveals shared genetic architecture and brain structural correlates of human cognitive abilities. [PDF]

Sci Rep
Chen H, Liao Y, Tang L, Wei X, Li T, Chen W.   +5 more
europepmc   +1 more source

Genetic insights into alcohol-associated liver disease: integrative transcriptome-wide analysis identifies novel susceptibility genes. [PDF]

Front Med (Lausanne)
Wang Q, Wang Z, Hu M, Liu F, Wang Z.
europepmc   +1 more source

Multitrait transcriptome‐wide association study (TWAS) tests

Genetic Epidemiology, 2021
AbstractMultitrait tests can improve power to detect associations between individual single‐nucleotide polymorphisms (SNPs) and several related traits. Here, we develop methods for multi‐SNP transcriptome‐wide association (TWAS) tests to test the association between predicted gene expression levels and multiple phenotypes.
Helian Feng, Nicholas Mancuso, Bogdan Paşaniuc, Peter Kraft   +3 more
semanticscholar   +4 more sources

Abstract 1591: Large-scale transcriptome-wide association study (TWAS) identifies novel candidate susceptibility genes for pancreatic cancer

Cancer Research, 2019
Abstract Pancreatic Ductal Adenocarcinoma (PDAC) is the third leading cause of cancer-related deaths in United States with a 5-year survival rate of only 8%. Inherited predisposition plays an important role in PDAC risk. Rare, moderately to highly penetrant mutations in hereditary cancer and pancreatitis genes, identified in families ...
Jun Zhong, Ashley Jermusyk, Lang Wu, Jason W. Hoskins, Irene Collins, Mingfeng Zhang, Lei Song, Charles C. Chung, Tongwu Zhang, Wenming Xiao, Rachael Z. Stolzenberg‐Solomon, Alison P. Klein, Brian M. Wolpin, Xiao‐Ou Shu, Stephen J. Chanock, Sara H. Olson, Nilanjan Chatterjee, Jill P. Smith, Jianxin Shi, Peter Kraft, Gloria M. Petersen, Wei Zheng, Laufey T. Ámundadóttir   +22 more
semanticscholar   +4 more sources

A-TWAS: An aggregated transcriptome-wide association study model incorporating multiple Bayesian priors

bioRxiv
AbstractMotivationTranscriptome-wide association study (TWAS) is a significant methodology utilized for identifying associations between genes and diseases by integrating transcriptome and genome-wide association studies (GWAS) data. The approach has been successful in pinpointing risk genes for various diseases, including Alzheimer’s disease ...
Yong Liang, Handong Wang, Yan Zhang
semanticscholar   +3 more sources

Transcriptome-wide association study (TWAS) of nasal respiratory epithelium and childhood asthma

Paediatric asthma and allergy, 2019
Erick Forno, Rong Zhang, Yale Jiang, Qi Yan, Yueh‐Ying Han, Edna Acosta‐Pérez, Nadia Boutaoui, Glorisa Canino, Wei Chen, Juan C. Celedón   +9 more
semanticscholar   +3 more sources

Cross-cancer cross-tissue Transcriptome-wide Association Study (TWAS) of 11 cancers identifies 56 novel genes

, 2020
Helian Feng, Arunabha Majumdar, Bogdan Paşaniuc, Hongjie Chen, Sara Lindström, Jeroen R. Huyghe, Stephanie L. Schmit, Tracy A. O’Mara, Deborah J. Thompson, Stuart MacGregor, Paul Brennan, James McKay, Richard S. Houlston, Beatrice Melin, Christopher I. Amos, Anne E. Cus, Mark M. Iles, Siddhartha Kar, Paul D.P. Pharoah, Rayjean J. Hung, Peter Kraft, BCAC, OCAC   +22 more
openalex   +2 more sources

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A cross-tissue transcriptome-wide association study identifies new susceptibility genes for insomnia.

Journal of Neurophysiology
Background: Despite a significant genetic component to insomnia (heritability: 22-25%), the genetic loci that modulate insomnia risk remain limited. Methods: We employed the Unified Test for Molecular Markers (UTMOST) for transcriptome-wide association ...
Li Li, Dongjin Wu, Cuiping Zhang, Xiaokun Lai, Ruolan Zhang, Shuhui Hu, Yifeng Ye   +6 more
semanticscholar   +1 more source

A cross-tissue transcriptome-wide association study identified susceptibility genes for age-related macular degeneration

Scientific Reports
Age-related macular degeneration (AMD) is a complex multifactorial disease with a significant genetic component. Despite extensive research efforts, the underlying molecular mechanisms remain elusive, necessitating innovative approaches to identify ...
Hongfan Yang, Haofei Huang, Kunlin Pu
semanticscholar   +1 more source

A cross-tissue transcriptome-wide association study identifies new susceptibility genes for benign prostatic hyperplasia

Scientific Reports
Benign prostatic hyperplasia (BPH) is a prevalent urinary system disorder. Despite evidence of a significant genetic component from previous studies, the specific pathogenic genes and biological mechanisms are still largely unknown.
Li Wang, Simin Chen, Jian-Wei Yang, Kangzhen Wang, Kun-peng Li, Shun Wan, Xiao-ran Li, Li Yang   +7 more
semanticscholar   +1 more source