Results 191 to 200 of about 8,166 (222)
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Endothelial Vasoactive Pathways and Renal Outcomes: A Drug-Target Mendelian Randomization and Transcriptome-Wide Association Study

Kidney Diseases
Introduction: Endothelium-mediated regulation of vascular tone plays a crucial role in modulating vascular functions, especially in the kidney, a highly vascularized organ.
Yixin Ma   +6 more
semanticscholar   +1 more source

Multi-ancestry Transcriptome-Wide Association Study Reveals Shared and Population-Specific Genetic Effects in Alzheimer’s Disease

bioRxiv
Alzheimer’s disease (AD) risk differs across ancestral populations, yet most genetic studies have focused on Non-Hispanic White (NHW) cohorts. We conducted a multi-population transcriptome-wide association study (TWAS) using whole-blood RNA-seq and ...
Xinyu Sun   +20 more
semanticscholar   +1 more source

A Cross-Tissue Transcriptome-Wide Association Study Reveals Novel Susceptibility Genes for Diabetic Kidney Disease in the FinnGen Cohort

Biomedicines
Background/Objectives: Diabetic kidney disease (DKD) is a common diabetic complication, driven by a multifactorial pathogenesis that includes various genetic components. However, the precise causative genes and their underlying biological pathways remain
Menghan Liu   +5 more
semanticscholar   +1 more source

Multi-ancestry transcriptome-wide association study identifies candidate genes associated with hepatoblastoma.

Cancer Epidemiology, Biomarkers and Prevention
BACKGROUND Hepatoblastoma (HB) is a rare embryonal liver tumor, with a rising global incidence that underscores the need to understand its genetic etiology.
Tiankai Xie   +17 more
semanticscholar   +1 more source

Genome and transcriptome wide association study identify candidate genes regulating folate levels in maize

Frontiers in Plant Science
Background Maize (Zea mays L.) serves as a crucial dietary source of folate for humans. However, the genetic regulatory mechanisms underlying the natural variation of folate in maize remain poorly understood. Here, we integrated multi-omics approaches to
Chenglin Zou   +5 more
semanticscholar   +1 more source

280 A Transcriptome-Wide Association Study of Intracranial Aneurysm Identifies Novel Risk Genes and Overlapping Genetic Architecture With Other Vascular Disorders

Neurosurgery
INTRODUCTION: Intracranial aneurysms (IAs) are common cerebrovascular lesions with well-documented heritability. Numerous genome-wide association studies (GWAS) have attempted to define IA genetic architecture.
Gunther Wong   +3 more
semanticscholar   +1 more source

Novel Susceptibility Genes for Sepsis Revealed by a Cross-Tissue Transcriptome-Wide Association Study.

Shock
BACKGROUND Sepsis, a life-threatening syndrome triggered by a dysregulated host response to infection, continues to impose a substantial global health burden.
Linfeng Tao   +6 more
semanticscholar   +1 more source

webTWAS 2.0: update platform for identifying complex disease susceptibility genes through transcriptome-wide association study

Nucleic Acids Research
Transcriptome-wide association study (TWAS) has successfully identified numerous complex disease susceptibility genes in the post-genome-wide association study (GWAS) era.
Chen Cao   +8 more
semanticscholar   +1 more source

Identification of candidate genes associated with milk production and mastitis based on transcriptome-wide association study.

Animal Genetics
Genetic research for the assessment of mastitis and milk production traits simultaneously has a long history. The main issue that arises in this context is the known existence of a positive correlation between the risk of mastitis and lactation ...
Sevda Hosseinzadeh   +3 more
semanticscholar   +1 more source

Older adult participation in cancer clinical trials: A systematic review of barriers and interventions

Ca-A Cancer Journal for Clinicians, 2021
Mina S Sedrak   +2 more
exaly  

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