Results 191 to 200 of about 451,072 (262)

Multi-omic analysis reveals maturation programs in human pluripotent stem cell-derived cardiomyocytes during long-term culture. [PDF]

J Mol Cell Cardiol
Feeney AK, Simmons AD, Bayne EF, Zhu Y, Park C, Peplinski CJ, Shabnam F, Zhang X, Zhang J, Pergande MR, Kamp TJ, Ge Y, Palecek SP.   +12 more
europepmc   +1 more source

Engineered Transformer Base Editor with Enhanced Editing Efficiency

Advanced Science, EarlyView.
A highly efficient transformer base editor system achieves robust genomic editing in a humanized mouse model. This work establishes a versatile and translatable platform, opening new avenues for precision gene therapy. ABSTRACT Canonical cytosine base editors (CBEs) achieve precise C‐to‐T conversions without inducing DNA double‐strand breaks (DSBs ...
Bowen Chen, Letong Liang, Rui Xu, Tianyi Wang, Hongyan Chen, Daru Lu   +5 more
wiley   +1 more source

Identification-Based Comparative Proteomic and Peptidomic Profiling of <i>Vespa mandarinia</i> and <i>Apis mellifera</i> Venoms Supported by De Novo Transcriptomic Annotation. [PDF]

Toxins (Basel)
Yang L, Li L, Dao J, Yang L, Yang Q.
europepmc   +1 more source

FTSJ3‐Mediated 2′‐O‐Methylation of HSPA5 mRNA Stabilizes BOP1 via SUMOylation to Drive DRP1‐Dependent Mitochondrial Fission and Fatty Acid Oxidation in Lung Squamous Cell Carcinoma

Advanced Science, EarlyView.
The RNA methyltransferase FTSJ3 drives lung squamous cell carcinoma progression by catalyzing 2′‐O‐methylation of HSPA5 mRNA, which stabilizes BOP1 through SUMOylation and activates DRP1/SREBP1‐mediated mitochondrial fission and fatty acid oxidation. Targeting this axis with liposomal siRNA potently suppresses tumor growth and metastasis ABSTRACT Lung ...
Qin Hu, Jiaheng Lin, Yifei Zhu, Ying Liu, Guoren Zhou   +4 more
wiley   +1 more source

Dataset of full-length transcriptome assembly and annotation of a two-year-old <i>Bupleurum chinense</i> DC. [PDF]

Data Brief
Gao Y, Wang B, Wang J, Xie Y, Wang J, Yang L, Zhang G, Wang H.   +7 more
europepmc   +1 more source

Expanding Genetic Code to Generate Human Brain Organoids with Both Vasculature and Microglia‐Like Cells

Advanced Science, EarlyView.
Using genetic code expansion, we engineered vascularized human cerebral organoids (vhCOs) with microglia‐like cells and blood‐brain barrier features. vhCOs recapitulate neurovascular interactions, regional identities, and neuronal subtypes resembling the fetal brain.
Haishuang Lin, Yaqing Wang, Hu Du, Yuxin Qin, Haoyu Zhang, Peng Wang, Lin Wei, Jianhua Qin   +7 more
wiley   +1 more source

Correction: Combined metabolome and transcriptome to analyze the regulatory network of key enzymes in the synthesis of senkirkine in Emilia sonchifolia. [PDF]

BMC Plant Biol
Yao J, Qin Y, Tu D, Huang Y, Liang L, Cai W, Huang M, Zhu X, Lao X.   +8 more
europepmc   +1 more source

The GPX3‐VCAM1 Axis Gates Pro‐Fibrotic Tubule Cell Fate in Hyperuricemic Nephropathy

Advanced Science, EarlyView.
Hyperuricemia induces NLRP3 inflammasome signaling activation and downregulation of GPX3 in proximal tubular epithelial cells, leading to oxidative stress–driven VCAM1 upregulation, emergence of pro‐fibrotic proximal tubule cells, macrophage recruitment, and renal fibrosis.
Yunfei Qi, Qiang Zhao, Yue Lve, Yaming Yuan, Tingting Zhou, Yue Yuan, Dexi Wu, Yifan Tang, Yan Liu, Zhigang Li, Chunping Jiang, Qiurong Ding   +11 more
wiley   +1 more source

Genome-Wide Identification of the <i>Castanea mollissima</i> MADS-Box Gene Family and Its Potential Roles in Female Flower Development Based on Transcriptomic and Morphological Analyses. [PDF]

Int J Mol Sci
Zeng L, Hu X, Yang H, Song J, Guo R, Zhang H, Zhang J, Guo C.   +7 more
europepmc   +1 more source