Results 61 to 70 of about 961,936 (200)

The Redox Homeostasis of Skeletal Muscle Cells Regulates Stage Differentiation of Toxoplasma gondii

Frontiers in Cellular and Infection Microbiology, 2021
Toxoplasma gondii is an obligatory intracellular parasite that causes persistent infections in birds and mammals including ~30% of the world’s human population.
Md. Taibur Rahman, Md. Taibur Rahman, Izabela J. Swierzy, Bryan Downie, Gabriela Salinas, Martin Blume, Martin Blume, Malcolm J. McConville, Carsten G. K. Lüder   +8 more
doaj   +1 more source

Cerebellum Transcriptome of Mice Bred for High Voluntary Activity Offers Insights into Locomotor Control and Reward-Dependent Behaviors. [PDF]

, 2016
The role of the cerebellum in motivation and addictive behaviors is less understood than that in control and coordination of movements. High running can be a self-rewarding behavior exhibiting addictive properties.
Caetano-Anollés, Kelsey, Garland, Theodore, Hernandez, Alvaro G, Perez, Sam D, Rhodes, Justin S, Rodriguez-Zas, Sandra L, Southey, Bruce R   +6 more
core   +2 more sources

Single-cell transcriptome profiling reveals neutrophil heterogeneity in homeostasis and infection

Nature Immunology, 2020
The full neutrophil heterogeneity and differentiation landscape remains incompletely characterized. Here, we profiled >25,000 differentiating and mature mouse neutrophils using single-cell RNA sequencing to provide a comprehensive transcriptional ...
Xuemei Xie, Q. Shi, Peng Wu, Xiaoyu Zhang, Hiroto Kambara, Jiayu Su, Hongbo Yu, Shin-Young Park, Rongxia Guo, Qian Ren, Sudong Zhang, Yuanfu Xu, L. Silberstein, T. Cheng, F. Ma, Cheng Li, Hongbo R. Luo   +16 more
semanticscholar   +1 more source

m6A RNA modifications are measured at single-base resolution across the mammalian transcriptome

Nature Biotechnology, 2022
Functional studies of the RNA N6-methyladenosine (m6A) modification have been limited by an inability to map individual m6A-modified sites in whole transcriptomes.
Lulu Hu, Shun Liu, Yong Peng, Ruiqi Ge, R. Su, Chamara Senevirathne, Bryan T. Harada, Qing Dai, Jiangbo Wei, Li-Sheng Zhang, Ziyang Hao, Liangzhi Luo, Huanyu Wang, Yuru Wang, M. Luo, Mengjie Chen, Jianjun Chen, Chuan He   +17 more
semanticscholar   +1 more source

Macromolecular crowding links ribosomal protein gene dosage to growth rate in Vibrio cholerae

BMC Biology, 2020
Background In fast-growing bacteria, the genomic location of ribosomal protein (RP) genes is biased towards the replication origin (oriC). This trait allows optimizing their expression during exponential phase since oriC neighboring regions are in higher
Alfonso Soler-Bistué, Sebastián Aguilar-Pierlé, Marc Garcia-Garcerá, Marie-Eve Val, Odile Sismeiro, Hugo Varet, Rodrigo Sieira, Evelyne Krin, Ole Skovgaard, Diego J. Comerci, Eduardo P. C. Rocha, Didier Mazel   +11 more
doaj   +1 more source

Characterization of the transcriptome, nucleotide sequence polymorphism, and natural selection in the desert adapted mouse Peromyscus eremicus [PDF]

, 2014
As a direct result of intense heat and aridity, deserts are thought to be among the most harsh of environments, particularly for their mammalian inhabitants. Given that osmoregulation can be challenging for these animals, with failure resulting in death,
Eisen, Michael B, MacManes, Matthew D
core   +4 more sources

The Landscape of Long Noncoding RNAs in the Human Transcriptome

Nature Genetics, 2015
Long noncoding RNAs (lncRNAs) are emerging as important regulators of tissue physiology and disease processes including cancer. To delineate genome-wide lncRNA expression, we curated 7,256 RNA sequencing (RNA-seq) libraries from tumors, normal tissues ...
Matthew K. Iyer, Y. Niknafs, Rohit Malik, Udit Singhal, Anirban Sahu, Yasuyuki Hosono, T. Barrette, John R. Prensner, Joseph R Evans, Shuang G Zhao, A. Poliakov, Xuhong Cao, S. Dhanasekaran, Yi-Mi Wu, D. Robinson, D. Beer, F. Feng, H. Iyer, A. Chinnaiyan   +18 more
semanticscholar   +1 more source

The Escherichia coli transcriptome mostly consists of independently regulated modules [PDF]

, 2019
Underlying cellular responses is a transcriptional regulatory network (TRN) that modulates gene expression. A useful description of the TRN would decompose the transcriptome into targeted effects of individual transcriptional regulators.
A Anand, A Biton, A Delorme, A Frigyesi, A Hyvärinen, A Santos-Zavaleta, A-M Martoglio, AE Teschendorff, B Dalrymple, B Langmead, B-K Cho, B-K Cho, BM Bolstad, C Vijayendran, CL Turnbough Jr, D Kim, D Marbach, D Risso, D-S Huang, DS Latchman, E Nudler, EJ O’Brien, ENCODE Project Consortium., ER Gansner, F Pedregosa, GI Guzmán, GI Guzmán, H Zou, HS Rhee, I Kristoficova, IM Keseler, J Pouyssegur, J Utrilla, JE Galagan, JJ Faith, JM Buescher, JM Engreitz, JM Monk, JT Leek, K Valgepea, K-K Yan, KF Jensen, KJ Karczewski, L Wang, M Ester, M Kim, M Lawrence, M Moretto, M Scott, M Scott, MB Gerstein, MI Love, NE Lewis, O Alter, P Chiappetta, P Comon, PR Subbarayan, PV Phaneuf, R De Smet, R Kolter, RA LaCroix, RB D’agostino, S Gama-Castro, S Lin, SJ Larsen, SW Seo, T Baba, T Barrett, TM Henkin, W Kong, W Liebermeister, W Saelens, X Zhang, Xin Fang, XW Zhang, Y Gao, Y Yamanaka, Z Wang   +77 more
core   +3 more sources

Transcriptome and genome sequencing uncovers functional variation in humans

Nature, 2013
Genome sequencing projects are discovering millions of genetic variants in humans, and interpretation of their functional effects is essential for understanding the genetic basis of variation in human traits.
T. Lappalainen, M. Sammeth, M. Friedländer, P. '. ’t Hoen, Jean Monlong, M. Rivas, Mar Gonzàlez-Porta, N. Kurbatova, Thasso Griebel, Pedro G. Ferreira, Matthias Barann, T. Wieland, Liliana Greger, M. van Iterson, J. Almlöf, Paolo Ribeca, I. Pulyakhina, Daniela Esser, T. Giger, Andrew Tikhonov, M. Sultan, Gabrielle Bertier, D. MacArthur, M. Lek, Esther Lizano, H. Buermans, Ismael Padioleau, T. Schwarzmayr, O. Karlberg, H. Ongen, Helena Kilpinen, S. Beltran, M. Gut, Katja Kahlem, V. Amstislavskiy, O. Stegle, M. Pirinen, S. Montgomery, P. Donnelly, M. McCarthy, Paul Flicek, T. Strom, H. Lehrach, S. Schreiber, R. Sudbrak, Á. Carracedo, S. Antonarakis, R. Häsler, A. Syvänen, G. van Ommen, A. Brazma, T. Meitinger, P. Rosenstiel, R. Guigó, I. Gut, X. Estivill, E. Dermitzakis   +56 more
semanticscholar   +1 more source

Decryption of sequence, structure, and functional features of SINE repeat elements in SINEUP non-coding RNA-mediated post-transcriptional gene regulation

Nature Communications
RNA structure folding largely influences RNA regulation by providing flexibility and functional diversity. In silico and in vitro analyses are limited in their ability to capture the intricate relationships between dynamic RNA structure and RNA ...
Harshita Sharma, Matthew N. Z. Valentine, Naoko Toki, Hiromi Nishiyori Sueki, Stefano Gustincich, Hazuki Takahashi, Piero Carninci   +6 more
doaj   +1 more source