Results 81 to 90 of about 602,244 (307)

Muscle transcriptome analysis reveals molecular pathways and biomarkers involved in extreme ultimate pH and meat defect occurrence in chicken

Scientific Reports, 2017
The processing ability and sensory quality of chicken breast meat are highly related to its ultimate pH (pHu), which is mainly determined by the amount of glycogen in the muscle at death.
Stéphane Beauclercq, Christelle Hennequet-Antier, Christophe Praud, Estelle Godet, Anne Collin, Sophie Tesseraud, Sonia Métayer-Coustard, Marie Bourin, Marco Moroldo, Frédéric Martins, Sandrine Lagarrigue, Elisabeth Le Bihan-Duval, Cécile Berri   +12 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Finding genome-transcriptome-phenome association with structured association mapping and visualization in GenAMap.

, 2011
Despite the success of genome-wide association studies in detecting novel disease variants, we are still far from a complete understanding of the mechanisms through which variants cause disease.
Junming Yin (5363774), Ross E. Curtis (574088), Eric P Xing (27712), Peter Kinnaird (5363987)   +3 more
core   +1 more source

Genome Wide Transcriptome Analysis of Dendritic Cells Identifies Genes with Altered Expression in Psoriasis [PDF]

, 2013
Activation of dendritic cells by different pathogens induces the secretion of proinflammatory mediators resulting in local inflammation. Importantly, innate immunity must be properly controlled, as its continuous activation leads to the development of ...
Szász, András, István Nagy (147904), Vilmos Tubak (455817), Kemény Lajos, Kondorosi, Éva, András Szász, Zoltán Hegedűs (455815), Tubak Vilmos, Lajos Kemény, Éva Kondorosi (3507242), Kata Filkor (455814), Kondorosi Éva, Nagy István, Tubák, Vilmos, Lajos Kemény (229288), Hegedűs Zoltán, Szász András, István Nagy, Kemény, Lajos, Éva Kondorosi, Nagy, István, Filkor, Katalin, Vilmos Tubak, Filkor Kata, Hegedűs, Zoltán, András Szász (455816), Kata Filkor, Zoltán Hegedűs   +27 more
core   +2 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Regional regulation of transcription in the chicken genome [PDF]

, 2010
Background Over the past years, the relationship between gene transcription and chromosomal location has been studied in a number of different vertebrate genomes. Regional differences in gene expression have been found in several different species.
Bastiaansen John WM, Nie, H., Nie Haisheng, Crooijmans, R.P.M.A., Groenen, M.A.M., Groenen Martien AM, Bastiaansen, J.W.M., Crooijmans Richard PMA, Megens, H.J.W.C., Megens Hendrik-Jan   +9 more
core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

CapTrap-seq: a platform-agnostic and quantitative approach for high-fidelity full-length RNA sequencing

Nature Communications
Long-read RNA sequencing is essential to produce accurate and exhaustive annotation of eukaryotic genomes. Despite advancements in throughput and accuracy, achieving reliable end-to-end identification of RNA transcripts remains a challenge for long-read ...
Sílvia Carbonell-Sala, Tamara Perteghella, Julien Lagarde, Hiromi Nishiyori, Emilio Palumbo, Carme Arnan, Hazuki Takahashi, Piero Carninci, Barbara Uszczynska-Ratajczak, Roderic Guigó   +9 more
doaj   +1 more source

High-Frequency Promoter Firing Links THO Complex Function to Heavy Chromatin Formation

Cell Reports, 2013
The THO complex is involved in transcription, genome stability, and messenger ribonucleoprotein (mRNP) formation, but its precise molecular function remains enigmatic.
John Mouaikel, Sébastien Z. Causse, Mathieu Rougemaille, Yves Daubenton-Carafa, Corinne Blugeon, Sophie Lemoine, Frédéric Devaux, Xavier Darzacq, Domenico Libri   +8 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source