Results 21 to 30 of about 499,194 (265)

Transcriptomic-metabolomic reprogramming in EGFR-mutant NSCLC early adaptive drug escape linking TGFβ2-bioenergetics-mitochondrial priming. [PDF]

, 2016
The impact of EGFR-mutant NSCLC precision therapy is limited by acquired resistance despite initial excellent response. Classic studies of EGFR-mutant clinical resistance to precision therapy were based on tumor rebiopsies late during clinical tumor ...
Bagai, Rakesh, Bivona, Trever G, Danielpour, David, Feng, Yan, Leahy, Patrick, Lindner, Daniel, Ma, Patrick C, Rosell, Rafael, Shi, Ivy, Thiagarajan, Praveena S, Veigl, Martina, Wu, Xiaoliang, Yin, Lihong, Zhang, Wei, Zhang, Zhenfeng   +14 more
core   +1 more source

Mapping genomic and transcriptomic alterations spatially in epithelial cells adjacent to human breast carcinoma. [PDF]

, 2017
Almost all genomic studies of breast cancer have focused on well-established tumours because it is technically challenging to study the earliest mutational events occurring in human breast epithelial cells.
Abdalla, Mohamed, Abdalla, Moustafa, Arneson, Nona, Boutros, Paul C, Cawthorn, Thomas R, Done, Susan J, Easson, Alexandra M, Fox, Natalie S, Iakovlev, Vladimir, Kanwar, Nisha, Kwan, Jennifer Yin Yee, Lee, Jennifer PY, Leong, Wey L, McCready, David, Miller, Naomi A, Moreno, Juan, Nair, Ranju, Tran-Thanh, Danh, Wang, Dong-Yu, Warren, Keisha, Youngson, Bruce J   +20 more
core   +2 more sources

Transcriptomics technologies

PLOS Computational Biology, 2017
© 2017 Lowe et al. Transcriptomics technologies are the techniques used to study an organism’s transcriptome, the sum of all of its RNA transcripts. The information content of an organism is recorded in the DNA of its genome and expressed through transcription.
Rohan Lowe, Neil Shirley, Mark Bleackley, Stephen Dolan, Thomas Shafee   +4 more
openaire   +6 more sources

Phenotypic and transcriptomic characterization of an ABA-sensitive mutant generated by microspore embryogenesis in barley

Journal of Plant Interactions, 2022
Barley (Hordeum vulgare L.) has been recognized as an ideal model plant to study the mechanism of environmental adaptation for crop improvement owing to its wide adaption to abiotic stresses. Abscisic acid is an essential hormone involved in many abiotic
Yingbo Li, Guimei Guo, Hongwei Xu, Yingjie Zong, Shuwei Zhang, Linli Huang, Runhong Gao, Ruiju Lu, Longhua Zhou, Chenghong Liu   +9 more
doaj   +1 more source

A preliminary transcriptomic approach to elucidate post harvest ripening of plum fruit [PDF]

, 2010
The aim of the present study was to dissect common and/or diverse mechanisms regulating plum (Prunus salicina) fruit ripening in genotypes characterized by different patterns of ethylene production. Fruit of an ethylenesuppressed cultivar ('Shiro') and a
Bonghi, Claudio, Manganaris, George A., Ramina, Angelo   +2 more
core   +2 more sources

Cell type-specific potential pathogenic genes and functional pathways in Alzheimer’s Disease

BMC Neurology, 2021
Background Alzheimer's disease (AD) is a pervasive age-related and highly heritable neurodegenerative disorder but has no effective therapy. The complex cellular microenvironment in the AD brain impedes our understanding of pathogenesis.
Xiao-Lan Wang, Lianjian Li
doaj   +1 more source

Transcriptome Analysis Reveals Key Genes and Pathways Associated with the Regulation of Flowering Time in Cabbage (Brassica oleracea L. var. capitata)

Plants, 2023
Flowering time is an important agronomic trait in cabbage (Brassica oleracea L. var. capitata), but the molecular regulatory mechanism underlying flowering time regulation in cabbage remains unclear.
Jiao Wang, Bin Zhang, Huiling Guo, Li Chen, Fengqing Han, Chao Yan, Limei Yang, Mu Zhuang, Honghao Lv, Yong Wang, Jialei Ji, Yangyong Zhang   +11 more
doaj   +1 more source

Transcriptomic analysis of field-droughted sorghum from seedling to maturity reveals biotic and metabolic responses. [PDF]

, 2019
Drought is the most important environmental stress limiting crop yields. The C4 cereal sorghum [Sorghum bicolor (L.) Moench] is a critical food, forage, and emerging bioenergy crop that is notably drought-tolerant.
Baker, Christopher R, Blow, Matthew J, Cole, Benjamin, Coleman-Derr, Devin, Dahlberg, Jeffery, DeGraaf, Stephanie, Gao, Cheng, Harrison, Maria J, Hollingsworth, Joy, Hutmacher, Robert, Jansson, Christer, Jeffers, Tim, Lemaux, Peggy G, Madera, Mary, Niyogi, Krishna K, O'Malley, Ronan C, Owiti, Judith A, Patel, Dhruv, Pierroz, Grady, Purdom, Elizabeth, Sievert, Julie, Singan, Vasanth R, Taylor, John W, Varoquaux, Nelle, Visel, Axel, Vogel, John P, Xu, Ling, Yoshinaga, Yuko   +27 more
core   +3 more sources

Understanding the metabolism of Mycoplasma mycoides subsp. capri in vitro by a transcriptomic analysis

Journal of Integrative Agriculture, 2018
It is generally known that the culture for mycoplasma is time-consuming and a variety of nutrients are needed in the culture medium. This brings a lot of difficulties to mycoplasma research and application, including Mycoplasma mycoides subsp. capri (Mmc)
Xiao-hui WANG, Yan-fang WANG, Hai-bi HUANG, Fan BAI, Xiao-na SHI, Chang-jiao MA, Yuan GAO, Jian-hua ZHANG, Wen-guang ZHANG, Yong-qing HAO   +9 more
doaj   +1 more source

A transcriptomic investigation of handicap models in sexual selection [PDF]

, 2014
We are grateful to D. Calder and T. Helps for access to study sites, and G. Murray-Dickson and M. Oliver for help with fieldwork and comments on manuscript drafts. This work was funded by NERC grant NE/D000602/1 (SBP), a NERC advanced fellowship (FM) and
Martinez-Padilla, Jesus, Mougeot, Francois, Paterson, Steve, Piertney, Stuart B., Webster, Lucy M. I., Wenzel, Marius Alexander   +5 more
core   +1 more source