Results 231 to 240 of about 225,084 (264)

Deciphering Anti‐Cancer Drug Efficacy Through Nanomechanical Vibrations in Living Gastric Cancer Organoids

Advanced Science, EarlyView.
This study developed an efficacy assessment platform that integrates patient‐derived gastric cancer organoids, atomic force microscopy (AFM)‐based nanomechanical vibration detection, deep learning analysis, and organoid mechanical modeling. It detects picomolar drug effects within 0.1 s signal, achieves 97% classification accuracy, and offers non ...
Ting Zhang, Qiubo Chen, Shihai Lan, Liang Zhu, Shuaiyu Liu, Yan Xia, Yalu Zhang, Hanhui Yao, Yongman Liu, Shangquan Wu, Qingchuan Zhang   +10 more
wiley   +1 more source

Characterizing intra- and intertumor heterogeneity in ovarian high-grade serous carcinoma subtypes using single-cell and spatial transcriptomics. [PDF]

Genome Res
Li W, Grieshober L, Gertz J, Ivich A, Doherty JA, Greene CS, Hicks SC.   +6 more
europepmc   +1 more source

Branching out or bearing fruit: how MADS-box transcription factors orchestrate maize ovule development. [PDF]

Plant Cell
Prakash V.
europepmc   +1 more source

Editorial: Integrative single-cell and spatial multiomics: charting cellular architecture and disease microenvironments. [PDF]

Front Bioinform
Chen W, Lu J, Guo W, Li B, Zhang H, Wang Y, Zhou Z, Xu R.   +7 more
europepmc   +1 more source

Mutation-resolved single-cell transcriptomics reveals enhanced β-amyloid clearance in TET2-mutant human monocytes. [PDF]

JCI Insight
Yang X, Fatima S, Sampere-Birlanga S, Ware A, Shumliakivska M, Zanders L, Radhakrishnan S, Luxán G, John D, Günther S, Mas-Peiro S, Dimmeler S, Zeiher AM, Abplanalp WT.   +13 more
europepmc   +1 more source

Spatial transcriptomic analysis of neurons at the glioma infiltration front: A case study. [PDF]

Brain Pathol
Satomi K, Takami H, Onizuka H, Saito K, Yoshioka T, Nagane M, Suzuki Y, Ichimura K, Shibahara J.   +8 more
europepmc   +1 more source