Results 81 to 90 of about 6,405,169 (259)

Layer‐Specific Dermal and Subcutaneous Delivery via Modular LNP–Hydrogel‐Integrated Threaded Microneedles

Advanced Science, EarlyView.
Guided by spatial transcriptomics and clinical validation, a threaded microneedle platform enables precise layer‐specific delivery across the dermis and subcutaneous tissue. By addressing distinct pathogenic remodeling in different skin layers, this strategy coordinates compartment‐specific intervention, restores tissue architecture, and offers a ...
Fangzhou Xie, Yixiang Zhang, Shifeng Ling, Yuxuan Huang, Yingying Wei, Rao Fu, Jiahao He, Baikun Liu, Lucia Zhou, Kaifeng Huo, Yida Wang, Qingfeng Li, Yawei Du, Wenguo Cui, Yun Xie   +14 more
wiley   +1 more source

Dual‐Targeted Biomimetic MoSe2 Nanozymes for Enhancing Peri‐Implant Soft Tissue Integration

Advanced Science, EarlyView.
A dual‐targeting biomimetic nanozyme, MoSe2@SPMM, selectively targets Staphylococcus aureus and oxidatively stressed macrophages. Near‐infrared activation couples contact‐enhanced photothermal bacterial eradication with reactive oxygen species scavenging to disrupt the pathogenic–immunological amplification loop.
Minghao Zhou, Miaomiao Tian, Jingwei Yu, Jiaxin Kang, Miaomiao Chen, Yue Yuan, Lizhi Liu, Hongbo Wei   +7 more
wiley   +1 more source

Efficacy and mechanisms of neuromodulation in the treatment of irritable bowel syndrome

Bioelectronic Medicine
Disorders of gut-brain interaction (DGBI), including irritable bowel syndrome (IBS), have a significant impact on patients, reducing their quality of life and work efficiency.
Kaijie Wang, Md Jahangir Alam, Xinya Lan, Fei Li, Jiande D. Z. Chen   +4 more
doaj   +1 more source

Smart control for functional electrical stimulation with optimal pulse intensity

Current Directions in Biomedical Engineering, 2016
Transcutaneous electrical stimulation is a common treatment option for patients suffering from spinal cord injury or stroke. Two major difficulties arise when employing electrical stimulation in patients: Accurate stimulation electrode placement and ...
Reinert Aljoscha, Loitz Jan C., Quandt Fanny, Schroeder Dietmar, Krautschneider Wolfgang H.   +4 more
doaj   +1 more source

Acid‐Responsive Nanobot‐Integrated Core‐Shell Microneedles Reprogram the Degenerative Annulus Fibrosus Microenvironment Through Epigenetic Suppression of Ferroptosis

Advanced Science, EarlyView.
An acid‐responsive core‐shell microneedle system normalizes the degenerative annulus fibrosus microenvironment by consuming pathological H+, generating O2, and providing NIR‐amplified redox buffering. Mechanistically, it epigenetically suppresses ferroptosis via DNMT3A‐dependent methylation of the ATF3 promoter, relieving ATF3‐mediated repression of ...
Lu Tan, Yan Zheng, Yue Lan, Zhuo Cheng, Siya Wang, Changqing Li, Yanqiu Wang, Minghan Liu   +7 more
wiley   +1 more source

Efficacy of Parasacral Transcutaneous Electrical Nerve Stimulation in Children with Refractory Detrusor Overactivity [PDF]

Objective: This study aimed to evaluate the effectiveness of parasacral transcutaneous electrical nerve stimulation (p-TENS) in children with detrusor overactivity (DO) who were subjected to standard medical treatment, urotherapy, and/or biofeedback ...
Uğur Aferin, Elif Altınay Kırlı, Berin Selçuk, Bülent Önal, AFERİN, Uğur, ALTINAY KIRLI, ELİF ALTINAY, Onal, Bulent, Selcuk, Berin   +7 more
core   +1 more source

Persistent Zn2+ Influx‐Mediated Deacetylation of ANXA2 Regulates the “Zn2+‐Autophagic Flux” and Alleviates Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Zinc transporter SLC39A14 sustains intracellular Zn2+ levels to activate SIRT3‑dependent ANXA2 deacetylation at K302. This modification weakens ANXA2‑mTOR binding and releases autophagic‑flux suppression in nucleus pulposus cells. Dysregulated Zn2+ homeostasis disrupts this axis to drive intervertebral disc degeneration.
Yuxin Jin, Yongcheng Chen, Yihao Xie, Dongyang Hu, Longhui Gong, Zhihua Chen, Linjie Chen, Minhao Gao, Qizhu Chen, Morgan Jones, Hui Wang, Xiuling You, Kenny Yat Hong Kwan, Shoutao Weng, Taidong Lyu, Xiang Chen, Yuxiao Zhu, Yusheng Wang, Bin Li, Xiangyang Wang, Xiaofeng Jia, Kailiang Zhou, Ouqiang Wu, Aimin Wu   +23 more
wiley   +1 more source

Transcutaneous electrical nerve stimulation in the treatment of patients with poststroke urinary incontinence

, 2014
Zhui-feng Guo,1,* Yi Liu,2,* Guang-hui Hu,1 Huan Liu,1 Yun-fei Xu11Department of Urology, 2Department of Neurology, Shanghai Tenth People’s Hospital, Tongji University, Shanghai, People’s Republic of China*These authors contributed equally ...
Guo ZF, Liu H, Liu Y, Hu GH, Xu YF
core  

Feasibility Study of a Take-Home Array-Based Functional Electrical Stimulation System With Automated Setup for Current Functional Electrical Stimulation Users With Foot-Drop [PDF]

, 2014
Objective To investigate the feasibility of unsupervised community use of an array-based automated setup functional electrical stimulator for current foot-drop functional electrical stimulation (FES) users. Design Feasibility study. Setting Gait
Thies, Sibylle B., Thies, Sibylle B, Sobuh, M., Heller, Ben W., Prenton, S, Good, TR, Kenney, Laurence P, Kenney, LPJ, Kenney, Laurence P., Barker, Anthony T, Healey, Jamie, Good, Timothy R., Heller, Ben W, Stapleton, C., Barker, Anthony T., Cooper, G; id_orcid, Howard, David, Stapleton, C, Kenney, L. P., Thies, SB, Prenton, S., Howard, D., Reeves, Mark L, Cooper, G., Williamson, T, Good, Timothy R, Healey, J., Stapleton, Claire, Sobuh, Mohammad, Heller, BW, Williamson, Tracey, Thies, S.B., Prenton, Sarah, Thies, SBA, Howard, D, Reeves, M.L., Kenney, LP, Sobuh, M, Reeves, Mark L., Barker, A.T., Good, T. R., Cooper, G, Cooper, Glen, Reeves, ML, Barker, AT, Healey, J, Heller, B.W.   +46 more
core   +1 more source

Programmable Self‐Heating Microneedle Patch for on‐Demand Postprandial Glucose Management

Advanced Science, EarlyView.
A programmable self‐heating microneedle patch enables on‐demand, timed‐sequence insulin delivery via user‐triggered quadrant activation. Each activation generates localized heat that melts a phase‐change barrier, accelerating drug release. In diabetic rats, sequential quadrant activation counteracts four meal‐mimicking glucose spikes over 24 h without ...
Yang Zhao, Guifang Pan, Jincai Zhang, Yue Gong, Wenjian Zhang, Huiling Shen, Xingxing Li, Yuehan Ouyang, Hanhan Xie, Jundong Shao   +9 more
wiley   +1 more source