Results 161 to 170 of about 107,649 (340)

Extracellular Vesicle Packaged TDP43 Derived From ECs Exacerbates Cigarette Tar‐Related Atherosclerosis Progression via Enhancing Macrophage Extracellular Traps

Advanced Science, EarlyView.
Cigarette tar triggers EC‐derived EVs carrying TDP43, which binds VDAC1 to boost MAMs, mitochondrial Ca2+ overload, and METs formation in macrophages, accelerating smoking‐related AS progression, while retinoic acid binds TDP43 to block this pathogenic cascade.
Xinxin Zhu, Yuwu Chen, Wei Meng, Biyi Xu, Junke Mou, Xiaolin Liu, Mengyang Wang, Qishuo Gu, Qianhui Sun, Man Li, Chen Zhao, Ming Zeng, Ying Lv, Boling Yi, Sheng Qu, Xiaoxuan Bai, Ji Li, Xing Luo, Sining Hu, Bo Yu, Haibo Jia   +20 more
wiley   +1 more source

Pharmacokinetic evaluation of a transdermal anastrozole-in-adhesive formulation

, 2018
Ralf Regenthal,1,* Margarita Voskanian,2,* Frank Baumann,1 Jens Teichert,1 Christian Brätter,2 Achim Aigner,1 Getu Abraham31Rudolf-Boehm-Institute of Pharmacology and Toxicology, Clinical Pharmacology, Faculty of Medicine, University of Leipzig ...
Aigner A, Baumann F, Voskanian M, Abraham G, Teichert J, Regenthal R, Brätter C   +6 more
core  

Targeting Macrophage‐Mediated Lymphatic Immunosuppression to Prevent Tumor Recurrence After Microwave Ablation

Advanced Science, EarlyView.
Incomplete microwave ablation induces animmunosuppressive microenvironment in tumor‐draining lymph nodes. An albumin‐based lipoprotein nanosystem enables coordinated delivery of immunomodulators to tumor‐draining lymph nodes and residual tumors, reverses post‐ablation immunosuppression, suppresses residual tumor growth, and promotes durable antitumor ...
Xuexia Shan, Yuting Shen, Xiaodong Hou, Fengshan Jin, Shaoyue Li, Weichen Xu, Weiwei Ren, Xiaowan Bo, Qiuyan Li, Shuo Liu, Weifan Hao, Chengzhong Peng, Huixiong Xu, Liping Sun, Wenwen Yue   +14 more
wiley   +1 more source

Dendrimer-coupled sonophoresis-mediated transdermal drug-delivery system for diclofenac

, 2015
Bin Huang,1 Wei-Jiang Dong,2 Gao-Yi Yang,3 Wei Wang,1 Cong-Hua Ji,1 Fei-Ni Zhou4 1Department of Ultrasound, First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 2Department of Ultrasonography, Tongxiang Chinese Medicine Hospital ...
Dong WJ, Ji CH, Wang W, Huang B, Zhou FN, Yang GY   +5 more
core  

Sustainable Hydrogel‐Forming Microneedle‐Reservoir Patches for Transdermal Delivery of Hydrophilic Macromolecules: Biopolymers, Green Manufacturing and Translation

Advanced Science, EarlyView.
Hydrogel‐forming microneedle (HFMN)‐reservoir patches provide a modular route for controlled transdermal delivery of hydrophilic biomacromolecules. The platform integrates skin‐barrier penetration, sustainable biopolymers, scalable green manufacturing, hydration‐driven transport, model‐cargo validation, and translational quality requirements.
Siddharth Mohanty, Mehmet Onur Aydogdu, Sijia Kang, Xinbo Li, Mohan Edirisinghe   +4 more
wiley   +1 more source

Clinical utility of transdermal delivery of oxybutynin gel via a metered-dose pump in the management of overactive bladder

, 2012
Adrian WaggDepartment of Medicine, University of Alberta, Edmonton, Alberta, CanadaAbstract: Oxybutynin is an efficacious treatment for overactive bladder, but its clinical utility is hampered by relative intolerability due to its side effect profile ...
Wagg A
core  

RBMS1 Contributes to Early Arteriovenous Fistula Neointimal Remodeling Through Modulation of VSMC Phenotypic Responses

Advanced Science, EarlyView.
Postoperative arteriovenous fistulas exhibit increased RBMS1 in vascular smooth muscle cells (VSMCs). In experimental AVFs, RBMS1 overexpression aggravates, whereas deletion attenuates, neointimal hyperplasia. RBMS1 binds MPZL1 mRNA and promotes exon 5 skipping to generate MPZL1‐Δ5, which interacts with G3BP1 to activate AKT, driving VSMC proliferation,
Zongda Li, Chengwei Zhang, Xinying Yu, Shuang Yao, Yiting Lai, Xiaozhu Sun, Yao Zhao, Xiaoyu Lan, Tingting Hu, Wenjin Li, Zhenzhen Ma, Huimin Ma, Zihan Wang, Haihai Liang, Jundong Jiao   +14 more
wiley   +1 more source

Transdermal permeability of triamcinolone acetonide lipid nanoparticles

, 2019
Zhenmiao Qin,1 Feng Chen,1,2 Demei Chen,1 Yong Wang,1,2 Yinfeng Tan,1,2 Junfeng Ban3 1School of Pharmacy, Hainan Medical University, Haikou, People’s Republic of China; 2Hainan Provincial Key Laboratory of R&D of Tropical Herbs, Hainan Medical
Chen DM, Ban JF, Chen F, Wang Y, Tan YF, Qin ZM   +5 more
core  

AI‐Assisted Recognition of Actual Ureteral and Pancreatic Injuries in Laparoscopic Colorectal Surgery: A Randomized Video Review Study

Annals of Gastroenterological Surgery, EarlyView.
AI‐generated anatomical highlighting improved surgeons' recognition of actual ureteral injuries during laparoscopic colorectal surgery, including recognition within predefined injury time‐code windows. No significant overall improvement was observed for pancreatic injury, and incorrect adverse‐event judgments did not increase in no‐injury videos. These
Shunjin Ryu, Teppei Kamada, Kai Neki, Asuka Kuwashima, Yuta Imaizumi, Shunsuke Nakashima, Yasuhiro Takano, Yasunobu Kobayashi, Yasuhiro Takeda, Ken Eto   +9 more
wiley   +1 more source

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +2 more sources