Results 101 to 110 of about 232,924 (282)

Transdermal nano suspension delivery of simvastatin: formulation optimization, physicochemical property and release characteristic evaluations

Materials Research Express
Simvastatin (SV), an anti-hyperlipidemic agent, exhibits poor absorption due to its first-pass metabolism, resulting in only 5% bioavailability. Hence, the primary goal of the current study is to overcome this problem by formulating SV into a nano ...
Zuheeb Ahmed, Ubed-Ur Rehman, Imran Suheryani, Marvi Metlo, Muhammad Usman Yasin, Asif Nawaz, Riyanto Teguh Widodo   +6 more
doaj   +1 more source

Formulation Design and Development of a Unani Transdermal Patch for Antiemetic Therapy and Its Pharmaceutical Evaluation

Scientifica, 2016
The Transdermal Drug Delivery System (TDDS) is one of the novel routes for systemic delivery of drugs through intact skin. A transdermal patch (TP) is a medicated patch that is placed on skin for delivery of medication through skin into the blood stream.
Mohd Nauman Saleem, Mohammad Idris
doaj   +1 more source

Persistent Zn2+ Influx‐Mediated Deacetylation of ANXA2 Regulates the “Zn2+‐Autophagic Flux” and Alleviates Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Zinc transporter SLC39A14 sustains intracellular Zn2+ levels to activate SIRT3‑dependent ANXA2 deacetylation at K302. This modification weakens ANXA2‑mTOR binding and releases autophagic‑flux suppression in nucleus pulposus cells. Dysregulated Zn2+ homeostasis disrupts this axis to drive intervertebral disc degeneration.
Yuxin Jin, Yongcheng Chen, Yihao Xie, Dongyang Hu, Longhui Gong, Zhihua Chen, Linjie Chen, Minhao Gao, Qizhu Chen, Morgan Jones, Hui Wang, Xiuling You, Kenny Yat Hong Kwan, Shoutao Weng, Taidong Lyu, Xiang Chen, Yuxiao Zhu, Yusheng Wang, Bin Li, Xiangyang Wang, Xiaofeng Jia, Kailiang Zhou, Ouqiang Wu, Aimin Wu   +23 more
wiley   +1 more source

Programmable Self‐Heating Microneedle Patch for on‐Demand Postprandial Glucose Management

Advanced Science, EarlyView.
A programmable self‐heating microneedle patch enables on‐demand, timed‐sequence insulin delivery via user‐triggered quadrant activation. Each activation generates localized heat that melts a phase‐change barrier, accelerating drug release. In diabetic rats, sequential quadrant activation counteracts four meal‐mimicking glucose spikes over 24 h without ...
Yang Zhao, Guifang Pan, Jincai Zhang, Yue Gong, Wenjian Zhang, Huiling Shen, Xingxing Li, Yuehan Ouyang, Hanhan Xie, Jundong Shao   +9 more
wiley   +1 more source

An update on the use of transdermal oxybutynin in the management of overactive bladder disorder

Therapeutic Advances in Urology, 2016
Antimuscarinic medications are used to treat nonneurogenic overactive bladder refractory to nonpharmacologic therapy. Side effects such as dry mouth, constipation, blurred vision, dizziness, and impaired cognition limit the tolerability of therapy and ...
Joshua A. Cohn, Elizabeth T. Brown, W. Stuart Reynolds, Melissa R. Kaufman, Douglas F. Milam, Roger R. Dmochowski   +5 more
doaj   +1 more source

Solid-State Stability Issues of Drugs in Transdermal Patch Formulations

, 2017
The transdermal patch formulation has many advantages, including noninvasiveness, an ability to bypass the first-pass metabolism, low dosage requirements, and prolonged drug delivery.
Pradhan, Adwait, Whang, Chang-Hee, Thakkar, Roshni, Apoorva Panda, Sharma, Purnendu Kumar, Adwait Pradhan, Murthy, S. Narasimha, Ruchi Thakkar, S. Narasimha Murthy, Thakkar, Ruchi, Michael A. Repka, Chang-Hee Whang, Panda, Apoorva, Purnendu Kumar Sharma, Jiaxiang Zhang, Repka, Michael A., Zhang, Jiaxiang   +16 more
core   +1 more source

Continuous Molecular Monitoring Using Electrochemical Aptamer‐Based Sensors: Remaining Challenges for Long‐Term In Vivo Deployment

Advanced Science, EarlyView.
Continuous molecular monitoring using electrochemical aptamer‐based sensors enables real‐time tracking of dynamic biomarkers with transformative potential for precision medicine. Achieving clinically relevant month‐long stability remains a central challenge due to multiple degradation pathways.
Shibo Liu, Xiangling Li, Wei Ouyang
wiley   +1 more source

Optimasi efektivitas sediaan transdermal patch natrium diklofenak [PDF]

, 2011
LAPORAN PENELITIAN INI MEMBAHAS TENTANG Optimasi efektivitas sediaan transdermal patch natrium ...
Isnaeni, Dr.,MS.,Apt, Esti Hendradi, Dra.,Apt.,MSi.,Ph.D, Junaidi Khotib, NIDN0022107001, Esti Hendradi, Dra.,Apt.,MSi.,PhD   +3 more
core   +1 more source

Formulasi Transdermal Patch Jahe Merah

Proses produksi transdermal patch jahe merah (Zingiber officinale var.rubrum) dilakukan dengan determinasi, ekstraksi, skrinning fitokimia, studi preformulasi, formulasi dan uji fisik.
Suryadinata, Rivan Virlando, Jalmav, Marthy Meliana Ariyanti, Lorensia, Amelia   +2 more
core   +2 more sources

Rotigotine Transdermal Patch for the Treatment of Restless Legs Syndrome

, 2014
Rotigotine, a nonergot dopamine agonist, has been developed as a novel transdermal formulation. The rotigotine transdermal patch has received EMA and FDA marketing authorization for the treatment of adult patients with early or advanced Parkinson's ...
Olivier Rascol, Santiago Perez-Lloret, Pietro Lucca Ratti, María Verónica Rey   +3 more
core   +1 more source