Results 31 to 40 of about 256,745 (264)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

High-performance co-oscillating electrochemical vector hydrophone based on integrated microelectrodes with microgrooves

Microsystems & Nanoengineering
This paper reports a high performance co-oscillating electrochemical vector hydrophone based on integrated microelectrodes with microgrooves. Through theoretical and simulation analysis, the influence of key parameters such as the spacing between anode ...
Honghao Zhang, Yulan Lu, lintao Hu, Qinghua Liu, Wenlang Zhao, Hongmin Jiang, Maoqi Zhu, Zhenyu Sun, Guangyang Gou, Deyong Chen, Junbo Wang   +10 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A Highly Sensitive and High-Resolution Resonant MEMS Electrostatic Field Microsensor Based on Electrostatic Stiffness Perturbation

Micromachines, 2023
This paper proposes a highly sensitive and high-resolution resonant MEMS electrostatic field sensor based on electrostatic stiffness perturbation, which uses resonant frequency as an output signal to eliminate the feedthrough interference from the ...
Xiangming Liu, Shanhong Xia, Chunrong Peng, Yahao Gao, Simin Peng, Zhouwei Zhang, Wei Zhang, Xuebin Xing, Yufei Liu   +8 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Neuronal activity in the ventral tegmental area during goal-directed navigation recorded by low-curvature microelectrode arrays

Microsystems & Nanoengineering
Navigating toward destinations with rewards is a common behavior among animals. The ventral tegmental area (VTA) has been shown to be responsible for reward coding and reward cue learning, and its response to other variables, such as kinematics, has also
Wei Xu, Mixia Wang, Gucheng Yang, Fan Mo, Yaoyao Liu, Jin Shan, Luyi Jing, Ming Li, Juntao Liu, Shiya Lv, Yiming Duan, Meiqi Han, Zhaojie Xu, Yilin Song, Xinxia Cai   +14 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Long-term stability strategies of deep brain flexible neural interface

npj Flexible Electronics
Flexible deep brain neural interfaces, as an important research direction in the field of neural engineering, have broad application prospects in areas such as neural signal detection, treatment of neurological diseases, and intelligent control systems ...
Shiya Lv, Zhaojie Xu, Fan Mo, Yu Wang, Yiming Duan, Yaoyao Liu, Luyi Jing, Jin Shan, Qianli Jia, Mingchuan Wang, Siyu Zhang, Yu Liu, Juntao Liu, Jinping Luo, Yirong Wu, Mixia Wang, Yilin Song, Xinxia Cai   +17 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Microelectrode arrays cultured with in vitro neural networks for motion control tasks: encoding and decoding progress and advances

Microsystems & Nanoengineering
Microelectrode arrays (MEAs) cultured with in vitro neural networks are gaining prominence in bio-integrated system research, owing to their inherent plasticity and emergent learning behaviors. Here, recent advances in motion control tasks utilizing MEAs-
Sihan Hua, Yaoyao Liu, Jinping Luo, Shangchen Li, Longhui Jiang, Pei Wu, Shutong Sun, Li Shang, Chengji Lu, Kui Zhang, Juntao Liu, Mixia Wang, Huaizhang Shi, Xinxia Cai   +13 more
doaj   +1 more source