Results 41 to 50 of about 294,368 (303)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
FEM-Based Design and Characterization of a Millimeter-Scale Piezoelectric Resonance Force Sensor
IEEE AccessThis paper presents a millimeter-scale piezoelectric effect-based force sensor that uses the change in its resonant frequency as the detection principle for high sensitivity and a wide measurement range.
Aoto Yamazaki +4 more
doaj +1 more source
Investigation of the structure of recording head fields [PDF]
, 1979 Head fields of two recording heads (gap lengths 2.1 and 2.8 micrometer) have been measured with the help of a series of magnetoresistive transducers. The widths of these transducers are 1.9, 4.1 and 7.0 micrometer and they have been positioned in the gap
Fluitman, J.H.J., Groenland, J.P.J.
core +2 more sources
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Applied Sciences, 2019 Fouling accumulation in pipelines is a well-known problem in industry across various applications. The build-up of fouling within a pipe can reach a detrimental state, leading to pipe blockages that, in turn, result in pipe bursts. As pipelines transport
Habiba Lais +3 more
doaj +1 more source
Integrated ultrasonic particle positioning and low excitation light fluorescence imaging [PDF]
, 2013 A compact hybrid system has been developed to position and detect fluorescent micro-particles by combining a Single Photon Avalanche Diode (SPAD) imager with an acoustic manipulator. The detector comprises a SPAD array, light-emitting diode (LED), lenses,
Al-Rawhani, M. +3 more
core +2 more sources
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Absolute calibration device of the vibration sensor
The Journal of Engineering, 2019 Vibration sensor calibration is performed using the absolute calibration method and the comparison calibration method. The comparative calibration method is used to take a carefully calibrated benchmark to the measured sensor and the vibration sensor for
Xu Bai
doaj +1 more source
Ultrasonic bone densitometer [PDF]
, 1974 A device, for measuring the density of a bone structure so as to monitor the calcium content, is described. A pair of opposed spaced ultrasonic transducers are held within a clamping apparatus closely adjacent the bone being analyzed.
Hoop, J. M.
core +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source