Results 51 to 60 of about 148,832 (285)

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Development of High-Speed On–Off Valves and Their Applications

Chinese Journal of Mechanical Engineering, 2022
With the widespread application of the computer and microelectronic technology in the industry, digitization becomes the inevitable developing trend of the hydraulic technology.
He Wang, Zhen Chen, Jiahai Huang, Long Quan, Bin Zhao   +4 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

High-speed mechano-active multielectrode array for investigating rapid stretch effects on cardiac tissue

Nature Communications, 2019
While strain is known to affect cardiac electrophysiology, experimental systems to interrogate the effect of rapid strain cycles on cardiac tissue are lacking.
Matthias Imboden, Etienne de Coulon, Alexandre Poulin, Christian Dellenbach, Samuel Rosset, Herbert Shea, Stephan Rohr   +6 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Microscale photoacoustic imaging via laser-induced ultrasound in microfluidic environments

JPhys Photonics
Photoacoustic (PA) imaging offers a powerful non-invasive approach for visualizing optically absorbing structures within biological tissues and microfluidic (MF) devices. While conventional PA imaging often relies on complex inverse problem solutions and
Jonathan U Álvarez-Martínez, R Castro-Beltrán, Gerardo Gutiérrez-Juárez, Gary A Baker, Luis Polo-Parada   +4 more
doaj   +1 more source

Parsing Unranked Tree Languages, Folded Once

Algorithms
A regular unranked tree folding consists of a regular unranked tree language and a folding operation that merges (i.e., folds) selected nodes of a tree to form a graph; the combination is a formal device for representing graph languages.
Martin Berglund, Henrik Björklund, Johanna Björklund   +2 more
doaj   +1 more source

A Comparative Study on Three Different Transducers for the Measurement of Nonlinear Solitary Waves

Sensors, 2013
In the last decade there has been an increasing interest in the use of highly- and weakly- nonlinear solitary waves in engineering and physics. Nonlinear solitary waves can form and travel in nonlinear systems such as one-dimensional chains of particles,
Piervincenzo Rizzo, Luyao Cai, Xianglei Ni   +2 more
doaj   +1 more source