Results 91 to 100 of about 507,984 (249)

Approximations and their consequences for dynamic modelling of signal transduction pathways [PDF]

, 2007
Signal transduction is the process by which the cell converts one kind of signal or stimulus into another. This involves a sequence of biochemical reactions, carried out by proteins.
Asthagiri, Atkins, Blüthgen, Briggs, Brightmann, Chen, Cho, Cornish-Bowden, Crampin, De Jong, Downward, Eissing, Eric Bullinger, Fell, Ferrell, Ferrell, Ferrell, Fowler, Goldbeter, Goldbeter, Hatakeyama, Heinrich, Heinrich, Huang, Johann Rohwer, Kholodenko, Kholodenko, Laurent, Lewis, Llórens, Markevich, Mathews, Michaelis, Novak, Olaf Wolkenhauer, Rubinow, Schilling, Schnell, Schoeberl, Segel, Swameye, Thomas Millat, Timmer, Tyson, Tzafriri, Winfree, Wolkenhauer, Wolkenhauer, Wolkenhauer, Yeung   +49 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Editorial: Gene therapy for the central and peripheral nervous system, volume II

Frontiers in Molecular Neuroscience, 2023
Andrew P. Tosolini, Andrew P. Tosolini, Andrew P. Tosolini, Andrew P. Tosolini, George M. Smith, George M. Smith   +5 more
doaj   +1 more source

High-performance nanoscale topological energy transduction

, 2017
The realization of high-performance, small-footprint, on-chip inductors remains a challenge in radio-frequency and power microelectronics, where they perform vital energy transduction in filters and power converters.
Gilbert, Matthew J., Philip, Timothy M.
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Risk of Bacteriophage Therapeutics to Transfer Genetic Material and Contain Contaminants Beyond Endotoxins with Clinically Relevant Mitigation Strategies

Infection and Drug Resistance, 2021
James B Doub Division of Clinical Care and Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USACorrespondence: James B DoubDivision of Infectious Diseases, University of Maryland School of Medicine, 725 ...
Doub JB
doaj  

The Apparatus of Belief: Prayer, Technology, and Ritual Gesture

Religions, 2016
Through a focus on the early history of a mass mediated ritual practice, this essay describes the “apparatus of belief,” or the specific ways in which individual religious belief has become intimately related to tele-technologies such as the radio.
Anderson Blanton
doaj   +1 more source

Generate, Transduct, Adapt: Iterative Transduction with VLMs

CoRR
Transductive zero-shot learning with vision-language models leverages image-image similarities within the dataset to achieve better classification accuracy compared to the inductive setting. However, there is little work that explores the structure of the language space in this context.
Oindrila Saha, Logan Lawrence, Grant Van Horn, Subhransu Maji   +3 more
openaire   +2 more sources

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source