Results 61 to 70 of about 507,984 (249)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Isolation of tissue-resident endothelial stem cells and their use in regenerative medicine

Inflammation and Regeneration, 2019
Background During sprouting angiogenesis, stalk cells, localized behind tip cells, generate endothelial cells (ECs) for the elongation of new vessels.
Tomohiro Iba, Hisamichi Naito, Shota Shimizu, Fitriana Nur Rahmawati, Taku Wakabayashi, Nobuyuki Takakura   +5 more
doaj   +1 more source

Functional Severe Acute Respiratory Syndrome Coronavirus 2 Virus-Like Particles From Insect Cells

Frontiers in Microbiology, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains a major epidemic threat since the beginning of 2020. Efforts to combat the virus and the associated coronavirus disease 2019 (COVID-19) disease are being undertaken worldwide.
Antonina Naskalska, Agnieszka Dabrowska, Agnieszka Dabrowska, Artur Szczepanski, Artur Szczepanski, Krzysztof P. Jasik, Beata Gromadzka, Beata Gromadzka, Krzysztof Pyrc   +8 more
doaj   +1 more source

Self-organization of signal transduction

, 2013
We propose a model of parameter learning for signal transduction, where the objective function is defined by signal transmission efficiency. We apply this to learn kinetic rates as a form of evolutionary learning, and look for parameters which satisfy ...
Scheler, Gabriele
core   +2 more sources

On the Monadic Second-Order Transduction Hierarchy [PDF]

, 2009
We compare classes of finite relational structures via monadic second-order transductions. More precisely, we study the preorder where we set C \subseteq K if, and only if, there exists a transduction {\tau} such that C\subseteq{\tau}(K).
A. Blumensath, A. Blumensath, Achim Blumensath, B. Courcelle, B. Courcelle, B. Courcelle, B. Courcelle, B. Courcelle and J. Engelfriet, B. Courcelle and S.-I. Oum, Bruno Courcelle, D. Seese, H. L. Bodlaender, J. Ne\v set\v ril and P. Osson, M. O. Rabin, N. Robertson and P. D. Seymour, N. Robertson and P. D. Seymour, S. Shelah, Wolfgang Thomas   +17 more
core   +3 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Current landscape of cystic fibrosis gene therapy

Frontiers in Pharmacology
Cystic fibrosis is a life-threatening disease that is caused by mutations in CFTR, a gene which encodes an ion channel that supports proper function of several epithelial tissues, most critically the lung.
Lindsey W. Plasschaert, Kelvin D. MacDonald, Kelvin D. MacDonald, Jeffrey S. Moffit   +3 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

CD28 and T cell antigen receptor signal transduction coordinately regulate interleukin 2 gene expression in response to superantigen stimulation. [PDF]

, 1992
Activation of an immune response requires intercellular contact between T lymphocytes and antigen-presenting cells (APC). Interaction of the T cell antigen receptor (TCR) with antigen in the context of major histocompatibility molecules mediates signal ...
Fraser, JD, Newton, ME, Weiss, A
core  

Fold-Hopf Bursting in a Model for Calcium Signal Transduction

, 2002
We study a recent model for calcium signal transduction. This model displays spiking, bursting and chaotic oscillations in accordance with experimental results. We calculate bifurcation diagrams and study the bursting behaviour in detail.
Brusch, Lutz, Bär, Markus, Kummer, Ursula, Lorenz, Wolfram, Or-Guil, Michal   +4 more
core   +1 more source