Results 91 to 100 of about 3,316,591 (299)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Effects of thermophoresis, Soret-Dufour on heat and mass transfer flow of magnetohydrodynamics non-Newtonian nanofluid over an inclined plate

Arab Journal of Basic and Applied Sciences, 2020
Heat together with mass transfer of magnetohydrodynamics (MHD) non-Newtonian nanofluid flow over an inclined plate embedded in a porous medium with influence of thermophoresis and Soret-Dufour is studied. The novelty of this study is the combined effects
A. S. Idowu, B. O. Falodun
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Numerical investigation on natural convective heat transfer of Al2O3-water nanofluids (About the effect of thermophysical properties)

Nihon Kikai Gakkai ronbunshu, 2016
Nanofluids are suspension dispersed nano-scale particles in a base fluid. In this study, natural convective heat transfer characteristics of Al2O3-water nanofluids in a vertical cylindrical container heated from below and cooled from above are ...
Masato AKAMATSU, Takuto KAMEYAMA, Yuki YOMOGITA, Mitsuo IWAMOTO, Hiroyuki OZOE   +4 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Analysis of fluid motion and heat transport on magnetohydrodynamic boundary layer past a vertical power law stretching sheet with hydrodynamic and thermal slip effects

AIP Advances, 2015
The present model is committed to the study of MHD boundary layer flow and heat transfer past a nonlinear vertically stretching porous stretching sheet with the effects of hydrodynamic and thermal slip.
Badr Alkahtani, M. Subhas Abel, Emad H. Aly   +2 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Heat transfer to impacting drops and post critical heat flux dispersed flow

, 1978
Heat transfer to drops impacting on a hot surface is examined in context of dispersions of flowing, boiling fluids. The liquid contribution to heat transfer from a hot tube to a two-phase dispersion is formulated in terms of heat transfer contributions ...
Kendall, Gail E., Rohsenow, Warren M.
core  

Stability Analysis of Mass Transfer on a Continuous Flat Plate Moving in Parallel or Reversely to a Free Stream in the Presence of Chemical Reaction by Haar Wavelets [PDF]

Journal of Applied and Computational Mechanics
This study investigates two-dimensional viscous incompressible boundary layer flow involving mass transfer above an uninterrupted flat surface in the presence of chemical reaction.
Vishwanath Awati, N. Mahesh Kumar, Akash Goravar   +2 more
doaj   +1 more source