Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Diagnostic and prognostic performance of Mxa and transfer function analysis-based dynamic cerebral autoregulation metrics. [PDF]
J Cereb Blood Flow Metab, 2022 Olsen MH +4 more
europepmc +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Prediction of the Responsiveness to Vagus-Nerve Stimulation in Patients with Drug-Resistant Epilepsy via Directed-Transfer-Function Analysis of Their Perioperative Scalp EEGs. [PDF]
J Clin Med, 2022 Kim D +7 more
europepmc +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
The structure and function of neurons with variable nonlinear transfer function
, 2005 One novel neuron with variable nonlinear transfer function is firstly proposed, It could also be called as subsection transfer function neuron. With different transfer function components, by virtue of multi-thresholded, the variable transfer function ...
Wang, SJ, Chinese Acad Sci, Inst Semicond, Lab Artificial Neural Networks, Beijing 100083, Peoples R China. +2 more
core
Dynamic characterisation of a linearised transfer function of non-ideal buck converters
The inherent nonlinear behaviour of DC-DC power supplies complicates the task of working out their linear models, which are essential for a model-oriented control.
Wilson, D., Bousbaine, A., Wiggins, B.
core +1 more source
CSEE Journal of Power and Energy SystemsEstablishing a suitable closed-loop transfer function model for the grid-connected PMSG system is the key basis in performing inter-harmonic characteristics analysis. Multiple closed-loop transfer functions can be constructed when different components of
Jingyi Li +5 more
doaj +1 more source
The Effect of Data Length on the Assessment of Dynamic Cerebral Autoregulation with Transfer Function Analysis in Neurological ICU Patients. [PDF]
Neurocrit Care, 2022 Zhang W +6 more
europepmc +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source