Results 131 to 140 of about 342,033 (283)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Cytoplasmic RNA-dependent RNA-synthesis in maturing chicken erythrocytes.

, 1976
Includes bibliographical references.An RNA-dependent RNA polymerase from ribosomes of maturing chicken erythrocytes was investigated. Concurrent with an increase in globin and RNA synthesis during phenylhydrazine induced anaemia, the total and specific ...
Boyd, Malcolm Charles David
core  

Third Radiation Transfer Model Intercomparison (RAMI) exercise: Documenting progress in canopy reflectance models

, 2007
The Radiation Transfer Model Intercomparison ( RAMI) initiative benchmarks canopy reflectance models under well-controlled experimental conditions.
Pinty, B., Lavergne, T., Lavergne, Thomas, Verhoef, Wouter, Robustelli, Monica, Gastellu-Etchegorry, J. P., Martin, E, Thompson, R., Lavergne, T, Lewis, P. E., Widlowski, J.L., Disney, M, Kuusk, Andres, Soler, Cyril, Taberner, M., Gastellu-Etchegorry, J.P., LeBlanc, S., Gobron, N., North, Peter R.J., Kuusk, A., Robustelli, M, Widlowski, Jean Luc, Verstraete, M. M., Ruiloba, R., Taberner, M, Xie, D., Gastellu-Etchegorry, JP, Disney, M.I., Robustelli, M., Lewis, Philip, Thompson, Richard, Mõttus, Matti; id_orcid, North, P. R.J., Rochdi, N, Ruiloba, R, Taberner, Malcolm, Verhoef, W., Verhoef, W, Verstraete, Michel M., Mottus, Matti, Fernandes, R, Widlowski, JL, Qin, W., Fernandes, Richard, Ruiloba, Rosario, Pinty, B, Leblanc, S, Lewis, PE, Gobron, N, Rochdi, N., North, PRJ, Disney, M., Peter North, Mottus, M, Mõttus, M., Qin, W, Bruniquel-Pinel, V., Disney, Mathias, Qin, Wenhan, Fernandes, R., Bruniquel-Pinel, Véronique, Rochdi, Nadia, Verstraete, M.M., Lewis, P.E., Widlowski, Jean-Luc, Widlowski, J.-L., Kuusk, A, Martin, E., Soler, C, Pinty, Bernard, Leblanc, Sylvain, Gastellu-Etchegorry, Jean-Philippe, Thompson, R, Bruniquel-Pinel, V, Martin, Eric, Soler, C., Xie, D, North, P.R.J., Gobron, Nadine, Verstraete, MM   +79 more
core   +1 more source

Amplitude and Phase Calibration with the Aid of Beacons in Microwave Imaging Radiometry by Aperture Synthesis: Algebraic Aspects and Algorithmic Implications

Remote Sensing
In remote sensing via aperture synthesis, the complex gains of every elementary antenna have to be very well known for measuring accurate complex visibilities.
Eric Anterrieu
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Irreversible repression of DNA synthesis in Fanconi anemia cells is alleviated by the product of a novel cyclin-related gene [PDF]

, 1995
Primary fibroblasts from patients with the genetic disease Fanconi anemia, which are hypersensitive to cross-linking agents, were used to screen a cDNA library for sequences involved in their abnormal cellular response to a cross-linking challenge.
Digweed, M., Günthert, U., Schneider, R., Friedl, R., Sperling, K., Seyschab, H.   +5 more
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Cortisol synthesis by primary human keratinocytes

, 2009
PhDCortisol analogues have been used to treat skin disorders, such as psoriasis and atopic dermatitis, for over 50 years but the ability of normal human keratinocytes to synthesise cortisol has not been reported.
Hannen, Rosalind Francesca
core  

Korobov’s controllability function method via orthogonal polynomials on [0,∞)

Visnik Harkivsʹkogo Nacionalʹnogo Universitetu im. V.N. Karazina. Cepiâ Matematika, Prikladna Matematika i Mehanika
Given a controllable system described by ordinary or partial differential equations and an initial state, the problem of finding a set of bounded positional controls that transfer the initial state to another state, not necessarily an equilibrium point ...
Abdon Choque, Tatjana Vukasinac
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source