Results 111 to 120 of about 342,033 (283)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Digital Sound Synthesis Based On Transfer Function Models

, 1999
Various methods for sound synthesis based on physical models have been presented. They start from a continuous model for the vibrating body, given by partial differential equations (PDEs), and employ proper discretization in time and space.
Rudolf Rabenstein, Lutz Trautmann
core  

A Proposed Method For Selecting The Clustering Algorithm In Radial Basis Function [QA223. A581 2008 f rb]. [PDF]

, 2008
Rangkaian Fungsi Asas Radial telah digunakan dengan meluas untuk menganggarkan dan mengelaskan data. Model biasa bagi Fungsi Asas Radial menentukan pusat, Radial Basis Function Networks have been widely used to approximate data and classify data.
Ang, Sau Loong
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Ladder network transfer function characteristics

, 1971
This thesis investigates the network characteristics and synthesis procedure previously developed. As a result of this investigation, location of the absolute minimum values of Navot\u27s method is determined; a procedure is given for obtaining more ...
Hatayodom, Thomtavanit
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Implementation Method and Bench Testing of Fractional-Order Biquadratic Transfer Function-Based Mechatronic ISD Suspension

Sensors
To address the challenge of physically realizing fractional-order electrical networks, this study proposes an implementation method for a mechatronic inerter–spring–damper (ISD) suspension based on a fractional-order biquadratic transfer function ...
Yujie Shen, Dongdong Qiu, Haolun Xu, Yanling Liu, Kecheng Sun, Xiaofeng Yang, Yan Guo   +6 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

METHOD OF SYNTHESIS OF ANALOG-DIGITAL CLOSED-FORM FILTERS WITH LINEAR PHASE AND FINISHED PULSE WEIGHTING FUNCTION FOR MULTI-CHANNEL INFORMATION-MEASURING SYSTEMS

Измерение, мониторинг, управление, контроль
Background. The article discusses a method for synthesizing closed-form analog-to-digital filters with linear phase and finite pulse weighting function.
B.V. Chuvykin, I.A. Dolgova
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source