Results 91 to 100 of about 342,033 (283)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Passivity Enforcement via Perturbation of Hamiltonian Matrices [PDF]
, 2004 This paper presents a new technique for the passivity enforcement of linear time-invariant multiport systems in statespace form. This technique is based on a study of the spectral properties of related Hamiltonian matrices.
Grivet-Talocia, S. +2 more
core +1 more source
Generalized Zero Shot Learning via Synthesis Pseudo Features
IEEE Access, 2019 Compared with conventional zero-shot learning (ZSL), generalized ZSL (GZSL) is more challenging because the test instances may come from seen and unseen classes.
Chuanlong Li +5 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Distributed texture-based terrain synthesis
, 2011 Terrain synthesis is an important field of Computer Graphics that deals with the generation of 3D landscape models for use in virtual environments. The field has evolved to a stage where large and even infinite landscapes can be generated in realtime ...
Tasse, Flora Ponjou
core
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
, 2017 The transfer-to method is a unique way to prepare bottlebrush polymers by reversible addition–fragmentation chain transfer (RAFT) polymerization. This little-studied bottlebrush polymer synthesis strategy is distinct from the grafting-from, grafting-to ...
Matson, J.B. +4 more
core +1 more source
SOLUTION OF THE PROBLEM OF THE AIR TEMPERATURE STABILIZATION IN THE CABIN OF THE VEHICLE
Авіаційно-космічна техніка та технологія, 2018 The subject matter of the article is the processes of synthesis of the automatic stabilization system (ASS) of the temperature in the vehicle cabin simulator using the vortex energy separator (VES) as the executive element of the system.
Сергей Николаевич Пасичник +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source