Results 101 to 110 of about 342,033 (283)

ON THE EQUIVALENCE OF DELAYED ARGUMENTS AND TRANSFER EQUATIONS FOR MODELING DYNAMIC SYSTEMS

open access: yesВавиловский журнал генетики и селекции, 2018
Development and improvement of mathematical methods used in modeling biological systems represents a topical issue of mathematical biology. In this paper, we considered a general form of a system of first-order delayed differential equations ...
V. A. Likhoshvai, T. M. Khlebodarova
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Vibration Characteristics of Heavy-Duty CNC Machine Tool-Foundation Systems

open access: yesShock and Vibration, 2018
Vibration characteristics of heavy CNC machine tools are directly affected by their foundations. To analyze vibrations of heavy CNC machine tools caused by internal and external loads, a system dynamics model of a rigid-flexible coupled heavy-duty CNC ...
Yang Tian   +3 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Computation of Inner-Outer Factorizations of Rational Matrices

open access: yes, 1997
In this paper we propose a new numerically reliable computational approach to determine the inner-outer factorization of a rational transfer matrix G of a linear descriptor system.
A. Varga, Andras Varga, Varga, A.
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Chemical synthesis of proteins: a tool for protein labeling

open access: yes, 2010
An ingenious stratagem useful to understand and modulate the structural and functional features of the proteins refers to the modification of their chemical structure.
De Rosa, Lucia
core  

Calixarene-based amphiphiles : synthesis, self-assembly and interaction with DNA [PDF]

open access: yes, 2015
The present doctoral thesis focused on the synthesis of amphiphilic calix[4]arenes, the study of their self-assembly properties at the air-water interface as Langmuir monolayers or in solution as nanoparticles and on the DNA-binding properties of the ...
Rullaud, Vanessa
core   +1 more source

Structural synthesis of discrete adaptive tracking systems based on the combined maximum principle

open access: yesAdvanced Engineering Research, 2017
Introduction. Discrepancy of the mathematical model structure to the observed process is one of the causes for loss in the control system operation. It determines the urgency of the problem of structural synthesis of the adaptive tracking systems which ...
Andrey A Kostoglotov   +4 more
doaj   +1 more source

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