Controlled evolution of an RNA enzyme [PDF]
It is generally thought that prior to the origin of protein synthesis, life on earth was based on self-replicating RNA molecules. This idea has become especially popular recently due to the discovery of catalytic RNA (ribozymes).
Joyce, G. F.
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Global microRNA Expression Profiling of Buffalo (Bubalus Bubalis) Embryos at Different Developmental Stages Produced by Somatic Cell Nuclear Transfer and in Vitro Fertilization Using Rna Sequencing [PDF]
, 2021 Pallavi Goel +5 more
openalex +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Mitochondrial DNA. Part B. Resources, 2019 In the present study, we determined the complete mitogenome of Opisina arenosella, the first for the family Xyloryctidae. This mitochondrial genome contains 15,389 bp, with an A + T content of 80.5% and consists of 13 protein-coding genes, 22 transfer ...
Rui Meng, Yao He, Su Ao, Bo Cai
doaj +1 more source
Mitochondrial DNA. Part B. Resources, 2020 The complete chloroplast genome of Chrysosplenium ramosum Maxim. and Chrysosplenium alternifolium L. were reported in this study. The chloroplast genomes were 153,460 bp for C. ramosum and 152,619 bp for C. alternifolium.
Wen-jie Yan +4 more
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Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Analysis of tRNA halves (tsRNAs) in serum from cattle challenged with bovine viral diarrhea virus
Genetics and Molecular BiologyAcute infections of bovine viral diarrhea virus (BVDV) lead to a range of clinical presentations. Laboratory tests for detection depend on collection of samples during a short viremia. Acutely infected animals remain largely undiagnosed.
Tasia M. Taxis +3 more
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A Unifying Scenario on the Origin and Evolution of Cellular and Viral Domains [PDF]
, 2009 The cellular theory on the nature of life has been one of the first major advancements in biology. Viruses, however, are the most abundant life forms, and their exclusion from mainstream biology and the Tree of Life (TOL) is a major paradox in biology ...
Claudiu I. Bandea
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Retrograde trafficking of Argonaute 2 acts as a rate-limiting step for de novo miRNP formation on endoplasmic reticulum–attached polysomes in mammalian cells [PDF]
, 2020 microRNAs are short regulatory RNAs in metazoan cells. Regulation of miRNA activity and abundance is evident in human cells where availability of target messages can influence miRNA biogenesis by augmenting the Dicer1-dependent processing of precursors ...
Barman, Bahnisikha +4 more
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