Results 151 to 160 of about 902,030 (357)
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
The Conformation of Transfer RNA
Kobunshi, 1972 一定の塩基配列で規定される転移リボ核酸(tRNA)は鎖内部での特異的塩基対形成によってクローバー葉形の二次構造をとる。三次元的にはクローバー葉構造が折りたたまれて高次構造を形成するが,その存在は主として熱変性過程の研究から明らかになった。t RNAのコンホメーションの安定化には陽イオン,とりわけ二価金属イオンが大きな効果を示す。Mg++,Mn++,Co++などはtRNAに約20～30個特異的に結合し,その会合定数は103～104の大きさである。ある種のtRNAには生物活性形と変性形が見出され,相互変換には二価イオンが決定的な役割を果す。活性形は約2～3個の二価イオン部位をよけいにもち,変換にはリン酸基の中和を伴うコンホメーション変化が起こると考えられる ...
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5\u27-Terminal nucleotide variations in human cytoplasmic tRNAHisGUG and its 5\u27-halves. [PDF]
, 2017 Transfer RNAs (tRNAs) are fundamental adapter components of translational machinery. tRNAs can further serve as a source of tRNA-derived noncoding RNAs that play important roles in various biological processes beyond translation.
Kirino, Yohei, Shigematsu, Megumi
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Molecular Oncology, EarlyView.Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.
Johan Staaf +10 more
wiley +1 more source
Investigation into the relationship between ethylene and sulfur assimilation in Arabidopsis thaliana and onion (Allium cepa L.) : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science (with Honours) in Biochemistry at Massey University [PDF]
, 2006 The phytohormone ethylene (C2H4) mediates the adaptive responses of plants to various nutrient deficiencies including iron (Fe)-deficiency, phosphorus (P)-deficiency and potassium (K)-deficiency.
Sanggang, Fiona Ann
core
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Inhibition of formylmethionyl-transfer RNA binding to ribosomes by tetracycline.
, 1968 Souvarish Sarkar, Robert E. Thach
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On the conformation of transfer RNA. [PDF]
Proceedings of the National Academy of Sciences, 1968 F, Cramer +4 more
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