A simplified method for purification of yeast “renaturable” leucine transfer RNA: The nucleotide sequence of fragments obtained by pancreatic ribonuclease digestion [PDF]
Simon H. Chang+3 more
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ABSTRACT Objective People with HIV (PWH) on antiretroviral therapy (ART) still experience neurocognitive dysfunction and accelerated brain volume loss. To assess whether the serotonergic and dopaminergic systems are affected, we used [11C]DASB positron emission tomography (PET) to assess presynaptic serotonergic function and [18F]FDOPA PET to measure ...
Chuen‐Yen Lau+12 more
wiley +1 more source
Transfer RNA-derived fragment tRF-36 modulates varicose vein progression via human vascular smooth muscle cell Notch signaling. [PDF]
Chen G, Yu C, Shi Y, Cai D, Zhou B.
europepmc +1 more source
Transfer RNA halves are found as nicked tRNAs in cells: evidence that nicked tRNAs regulate expression of an RNA repair operon. [PDF]
Chen X, Wolin SL.
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Yi‐Fei‐Jie‐Du‐Tang (YFJDT), a traditional Chinese medicine, has shown potential in lung cancer treatment by targeting key pathways. This study explores the mechanisms of YFJDT using bioinformatics, xenograft models, and A549 cells, demonstrating that YFJDT downregulates HIF1A, promotes ferroptosis, and inhibits epithelial‐mesenchymal transition (EMT ...
Shanshan Wang+6 more
wiley +1 more source
Altered blood and keratinocyte microRNA/transfer RNA fragment profiles related to fibromyalgia syndrome and its severity. [PDF]
Erbacher C+10 more
europepmc +1 more source
Structural analysis of spermine and magnesium ion binding to yeast phenylalanine transfer RNA. [PDF]
Gary J. Quigley+2 more
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Hypoxia promotes the epithelial‐mesenchymal transition (EMT) of renal tubular epithelial cells via the SIRT1‐FoxO1‐FoxO3‐autophagy pathway, thereby resulting in the fibrosis of renal tubular epithelial cells. Activation of SIRT1 or induction of autophagy inhibits this process, alleviating hypoxia‐induced fibrosis.
Guangyu Wang+6 more
wiley +1 more source
Transfer RNA-derived small RNA serves as potential non-invasive diagnostic marker and a novel therapeutic target for acute pancreatitis. [PDF]
Zhang J, Ou CL.
europepmc +1 more source