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International Journal of Rheumatic Diseases, 2018
Osteoporosis is one of the common orthopedic diseases featured in low bone mineral density. Exosomes have been proven to be potential markers for many diseases and health problems.
Yan Zhang +6 more
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Osteoporosis is one of the common orthopedic diseases featured in low bone mineral density. Exosomes have been proven to be potential markers for many diseases and health problems.
Yan Zhang +6 more
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Transfer RNA-Derived Small Non-Coding RNA: Dual Regulator of Protein Synthesis
Molecules and Cells, 2019Transfer RNA-derived small RNAs (tsRNAs) play a role in various cellular processes. Accumulating evidence has revealed that tsRNAs are deeply implicated in human diseases, such as various cancers and neurological disorders, suggesting that tsRNAs should ...
H. Kim
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Transfer RNA nucleotidyltransferase repairs all transfer RNAs randomly
Journal of Molecular Biology, 1977Total Escherichia coli transfer RNA was converted to tRNA-C-C by periodate oxidation and partially repaired with either E. coli or rabbit liver tRNA nucleotidyltransferase. Aminoacylation of the partially repaired molecules indicated that individual tRNA species were each repaired to the same extent as the total population of molecules.
Jeffrey A. Evans, Murray P. Deutscher
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Mitochondrial transfer RNAs in yeast: identification of isoaccepting transfer RNAs
Biochemistry, 1978To delineate the total number of tRNAs encoded by yeast mitochondrial DNA (mtDNA), we have examined mitochondrial tRNA preparations for the presence of heterogenic isoaccepting tRNAs. Analyses of /sup 3/H-labeled aminoacylated mitochondrial tRNAs by reversed-phase column chromatography (RPC-5) coupled with hybridization to mtDNA detected only one major
Nancy C. Martin, Murray Rabinowitz
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Discovery and function of transfer RNA‐derived fragments and their role in disease
Wiley Interdisciplinary Reviews - RNA, 2017Until recently, transfer RNAs (tRNAs) were thought to function in protein translation only. However, recent findings demonstrate that both pre‐ and mature tRNAs can undergo endonucleolytic cleavage by different ribonucleases originating different types ...
A. R. Soares, Manuel A. S. Santos
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Annual Review of Genetics, 1972
Initially the only way of identifying tRNA genes was by DNA-RNA hy bridization. The discovery that informational suppression may result from muta tions in tRNA genes has not only allowed their genetic analysis but has led to the isolation of mutants important in understanding the function, structure, and synthesis of tRNA.
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Initially the only way of identifying tRNA genes was by DNA-RNA hy bridization. The discovery that informational suppression may result from muta tions in tRNA genes has not only allowed their genetic analysis but has led to the isolation of mutants important in understanding the function, structure, and synthesis of tRNA.
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1978
1. Altered column-chromatographic profiles of a number of hepatoma and other tumor aminoacyl-tRNAs have been observed, most frequently for tRNAPhe, tRNAAsp, tRNAAsn, tRNATyr, tRNAHis, and tRNASer. 2. The chemical basis for the chromatographic alterations is still obscure, except that a tRNAPhe in Morris hepatoma 7777, which is not ...
Erika Randerath +2 more
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1. Altered column-chromatographic profiles of a number of hepatoma and other tumor aminoacyl-tRNAs have been observed, most frequently for tRNAPhe, tRNAAsp, tRNAAsn, tRNATyr, tRNAHis, and tRNASer. 2. The chemical basis for the chromatographic alterations is still obscure, except that a tRNAPhe in Morris hepatoma 7777, which is not ...
Erika Randerath +2 more
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Effect of Spermine on Transfer RNA and Transfer RNA-Ribosome Interactions
1988Translation of genetic message requires a coordianted interplay of more than a hundred kinds of macromolecules. Besides the ribosomes, which are multicomponent ribonucleoprotein particles by their own nature, molecules of transfer RNA, aminoacyl-tRNA synthetases, soluble protein factors and mRNA are involved in the process.
Ivana Weygand-Durasevic +4 more
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Transfer RNA Modification: Presence, Synthesis, and Function
EcoSal Plus, 2014Transfer RNA (tRNA) from all organisms on this planet contains modified nucleosides, which are derivatives of the four major nucleosides. tRNA from Escherichia coli/Salmonella enterica serovar Typhimurium contains 33 different modified nucleosides, which
G. Björk, T. Hagervall
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A study of transfer RNA methylation
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1973Abstract The process of enzymatic methylation was studied with yeast tRNAVal1, using as a source of enzyme the protein fraction precipitated from the 105 000 × g supernatant of both rat liver and hepatoma by 50 % (NH4)2SO4 saturation. Under the conditions chosen, the extent of methylation with the hepatoma enzyme was about 1 mole of methyl ...
T.V. Venkstern +2 more
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