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Crystallization of Transfer RNA

Nature, 1968
A bacterial transfer RNA (tRNAFMet) has been obtained in micro-crystalline form. Its probable unit cell dimensions have been deduced from X-ray powder photographs.
K. A. Marcker   +8 more
openaire   +3 more sources

Evolution of transfer RNA

Journal of Molecular Biology, 1973
Abstract Evolution by gene duplication and subsequent divergence is indicated by similarities common to 43 different transfer RNAs. Pairwise comparisons of these tRNAs reveal additional similarity, greatest for certain pairs of tRNAs for the same amino acid in the same organism, and also occurring in certain pairs of tRNAs for different amino acids ...
Sharon Pangburn   +2 more
openaire   +3 more sources

Transfer RNA‐derived fragments as potential exosome tRNA‐derived fragment biomarkers for osteoporosis

International Journal of Rheumatic Diseases, 2018
Osteoporosis is one of the common orthopedic diseases featured in low bone mineral density. Exosomes have been proven to be potential markers for many diseases and health problems.
Yan Zhang   +6 more
semanticscholar   +1 more source

Transfer RNA nucleotidyltransferase repairs all transfer RNAs randomly

Journal of Molecular Biology, 1977
Total Escherichia coli transfer RNA was converted to tRNA-C-C by periodate oxidation and partially repaired with either E. coli or rabbit liver tRNA nucleotidyltransferase. Aminoacylation of the partially repaired molecules indicated that individual tRNA species were each repaired to the same extent as the total population of molecules.
Jeffrey A. Evans, Murray P. Deutscher
openaire   +3 more sources

Mitochondrial transfer RNAs in yeast: identification of isoaccepting transfer RNAs

Biochemistry, 1978
To delineate the total number of tRNAs encoded by yeast mitochondrial DNA (mtDNA), we have examined mitochondrial tRNA preparations for the presence of heterogenic isoaccepting tRNAs. Analyses of /sup 3/H-labeled aminoacylated mitochondrial tRNAs by reversed-phase column chromatography (RPC-5) coupled with hybridization to mtDNA detected only one major
Nancy C. Martin, Murray Rabinowitz
openaire   +3 more sources

Transfer RNA in Hepatomas

1978
1. Altered column-chromatographic profiles of a number of hepatoma and other tumor aminoacyl-tRNAs have been observed, most frequently for tRNAPhe, tRNAAsp, tRNAAsn, tRNATyr, tRNAHis, and tRNASer. 2. The chemical basis for the chromatographic alterations is still obscure, except that a tRNAPhe in Morris hepatoma 7777, which is not ...
Erika Randerath   +2 more
openaire   +3 more sources

Transfer RNA-Derived Small Non-Coding RNA: Dual Regulator of Protein Synthesis

Molecules and Cells, 2019
Transfer RNA-derived small RNAs (tsRNAs) play a role in various cellular processes. Accumulating evidence has revealed that tsRNAs are deeply implicated in human diseases, such as various cancers and neurological disorders, suggesting that tsRNAs should ...
H. Kim
semanticscholar   +1 more source

GENETICS OF TRANSFER RNA

Annual Review of Genetics, 1972
Initially the only way of identifying tRNA genes was by DNA-RNA hy­ bridization. The discovery that informational suppression may result from muta­ tions in tRNA genes has not only allowed their genetic analysis but has led to the isolation of mutants important in understanding the function, structure, and synthesis of tRNA.
openaire   +3 more sources

Effect of Spermine on Transfer RNA and Transfer RNA-Ribosome Interactions

1988
Translation of genetic message requires a coordianted interplay of more than a hundred kinds of macromolecules. Besides the ribosomes, which are multicomponent ribonucleoprotein particles by their own nature, molecules of transfer RNA, aminoacyl-tRNA synthetases, soluble protein factors and mRNA are involved in the process.
Ivana Weygand-Durasevic   +4 more
openaire   +3 more sources

A study of transfer RNA methylation

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1973
Abstract The process of enzymatic methylation was studied with yeast tRNAVal1, using as a source of enzyme the protein fraction precipitated from the 105 000 × g supernatant of both rat liver and hepatoma by 50 % (NH4)2SO4 saturation. Under the conditions chosen, the extent of methylation with the hepatoma enzyme was about 1 mole of methyl ...
T.V. Venkstern   +2 more
openaire   +4 more sources

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