Results 31 to 40 of about 4,678,084 (301)
Human transfer RNA modopathies: diseases caused by aberrations in transfer RNA modifications
The FEBS Journal, 2020 tRNA molecules are post‐transcriptionally modified by tRNA modification enzymes. Although composed of different chemistries, more than 40 types of human tRNA modifications play pivotal roles in protein synthesis by regulating tRNA structure and stability
T. Chujo, K. Tomizawa
semanticscholar +1 more source
Mitochondrial DNA. Part B. Resources, 2019 Genetic innovation may be linked to evolutionary success, and indeed, the invasive round goby mitochondrial genome sequence carries two novel features not previously described in Benthophilinae.
Silvia Gutnik +2 more
doaj +1 more source
Transfer RNA demethylase ALKBH3 promotes cancer progression via induction of tRNA-derived small RNAs
Nucleic Acids Research, 2018 Transfer RNA is heavily modified and plays a central role in protein synthesis and cellular functions. Here we demonstrate that ALKBH3 is a 1-methyladenosine (m1A) and 3-methylcytidine (m3C) demethylase of tRNA.
Zhuojia Chen +9 more
semanticscholar +1 more source
Alternative genetic code for amino acids and transfer RNA revisited
Biomolecular Concepts, 2013 The genetic code is highly conserved among all organisms and its evolution is thought to be strictly limited. However, an increasing number of studies have reported non-standard codes in prokaryotic and eukaryotic genomes.
Hamashima Kiyofumi, Kanai Akio
doaj +1 more source
Tissue-specific differences in human transfer RNA expression. [PDF]
PLoS Genetics, 2006 Over 450 transfer RNA (tRNA) genes have been annotated in the human genome. Reliable quantitation of tRNA levels in human samples using microarray methods presents a technical challenge.
Kimberly A Dittmar +2 more
doaj +1 more source
Modifications and functional genomics of human transfer RNA
Cell Research, 2018 Transfer RNA (tRNA) is present at tens of millions of transcripts in a human cell and is the most abundant RNA in moles among all cellular RNAs. tRNA is also the most extensively modified RNA with, on an average, 13 modifications per molecule.
T. Pan
semanticscholar +1 more source
Exploration of Targeted Anti-tumor Therapy, 2023 Aim: Recently, a tumor cell-platelet interaction was identified in different tumor entities, resulting in a transfer of tumor-derived RNA into platelets, named further “tumor-educated platelets (TEP)”.
Lisa T. Huber +9 more
doaj +1 more source
Mitochondrial DNA. Part B. Resources, 2021 The current study describes the complete mitochondrial genome (mitogenome) of an egg parasitoid wasp, Telenomus remus Nixon 1937. This mitogenome is 16,014 bp in length, consisting of 37 typical coding genes (13 protein-coding genes, 22 transfer RNA ...
Weiwei Li, Yunfei Wu, Bin Chen
doaj +1 more source
Transfer RNA-derived small RNA: an emerging small non-coding RNA with key roles in cancer
Experimental Hematology & Oncology, 2022 Transfer RNAs (tRNAs) promote protein translation by binding to the corresponding amino acids and transporting them to the ribosome, which is essential in protein translation.
Xinliang Gu +5 more
doaj +1 more source
Deep transfer learning of cancer drug responses by integrating bulk and single-cell RNA-seq data
Nature Communications, 2022 Drug screening data from massive bulk gene expression databases can be analyzed to determine the optimal clinical application of cancer drugs. The growing amount of single-cell RNA sequencing (scRNA-seq) data also provides insights into improving ...
Junyi Chen +7 more
semanticscholar +1 more source