Results 61 to 70 of about 4,926,306 (277)

Nanodelivery of a functional membrane receptor to manipulate cellular phenotype. [PDF]

, 2018
Modification of membrane receptor makeup is one of the most efficient ways to control input-output signals but is usually achieved by expressing DNA or RNA-encoded proteins or by using other genome-editing methods, which can be technically challenging ...
Baikoghli, Mo, Cheng, R Holland, Coleman, Matthew A, He, Wei, Patriarchi, Tommaso, Shen, Ao, Tian, Lin, Xiang, Yang K   +7 more
core   +2 more sources

RNA Secondary Structures: Complex Statics and Glassy Dynamics

, 2008
Models for RNA secondary structures (the topology of folded RNA) without pseudo knots are disordered systems with a complex state-space below a critical temperature.
Burghardt, B., Hartmann, A. K., Mann, A., Wolfsheimer, S.   +3 more
core   +1 more source

The First Strand Transfer during HIV-1 Reverse Transcription Can Occur either Intramolecularly or Intermolecularly [PDF]

, 1998
Reverse transcription is a complicated process that involves at least two cDNA transfer reactions to produce a full-length copy DNA of the retroviral RNA genome.
Berkhout, Ben, van Wamel, Jeroen L.B.
core   +2 more sources

A CRISPR-Cas9-based reporter system for single-cell detection of extracellular vesicle-mediated functional transfer of RNA

Nature Communications, 2020
Extracellular vesicles (EVs) form an endogenous transport system for intercellular transfer of biological cargo, including RNA, that plays a pivotal role in physiological and pathological processes.
O. G. de Jong, Daniel E. Murphy, Imre Mäger, Eduard Willms, Antonio Garcia-Guerra, Jerney J. Gitz-Francois, J. Lefferts, Dhanu Gupta, S. Steenbeek, J. van Rheenen, S. El Andaloussi, R. Schiffelers, M. Wood, P. Vader   +13 more
semanticscholar   +1 more source

A single H/ACA small nucleolar RNA mediates tumor suppression downstream of oncogenic RAS. [PDF]

, 2019
Small nucleolar RNAs (snoRNAs) are a diverse group of non-coding RNAs that direct chemical modifications at specific residues on other RNA molecules, primarily on ribosomal RNA (rRNA).
Blanchard, Scott C, Calvert, Meredith E, Chen, Bin, Contreras, Adrian, Forester, Craig M, Gill, Ryan M, Gordan, John D, Holm, Mikael, Jackson, Cody, Kelley, R Kate, Luk, John M, McMahon, Mary, Pang, Xiaming, Quigley, David A, Ruggero, Davide, Uechi, Tamayo   +15 more
core   +1 more source

Prebiotic chiral transfer from self-aminoacylating ribozymes may favor either handedness. [PDF]

Modern life is essentially homochiral, containing D-sugars in nucleic acid backbones and L-amino acids in proteins. Since coded proteins are theorized to have developed from a prebiotic RNA World, the homochirality of L-amino acids observed in all known ...
Brunton, Krishna, Chen, Irene, Dworkin, Jason, Janzen, Evan, Kenchel, Josh, Li, Weiwei, Liu, Ziwei, Parker, Eric, Schultz, Kyle, Vázquez-Salazar, Alberto, Wells, Reno   +10 more
core   +1 more source

Nucleic-acid recognition interfaces: How the greater ability of RNA duplexes to bend towards the surface influences electrochemical sensor performance [PDF]

, 2015
The influence of RNA versus DNA on the performance of electrochemical biosensors where redox-labelled nucleic acid duplexes bend towards the electrode surface has been assessed.
Abhayawardhana, Anne, Anne, Boon, Ciampi, Creager, D. Brynn Hibbert, Dong, Farjami, Gilbert, Gyi, Husken, Husken, Ikeda, J. Justin Gooding, Krishnan, Laviron, Lubin, Macdonald, Mearns, Medina, Nadim Darwish, Noy, Odenthal, Perez, Peterson, Pramanik, Prigodich, Roya Tavallaie, Selcuklu, Shakked, Steel, Tavallaie, Tavallaie, White, Wong, Wu, Yang, Zhou   +38 more
core   +1 more source

GtRNAdb: a database of transfer RNA genes detected in genomic sequence

Nucleic Acids Res., 2008
Transfer RNAs (tRNAs) represent the single largest, best-understood class of non-protein coding RNA genes found in all living organisms. By far, the major source of new tRNAs is computational identification of genes within newly sequenced genomes.
Patricia P. Chan, T. Lowe
semanticscholar   +1 more source

Unraveling RNA by Mechanical Unzipping [PDF]

arXiv, 2023
We review the basic concepts and tools for mechanically unzipping RNA hairpins using force spectroscopy. By pulling apart the ends of an RNA molecule using optical tweezers, it is possible to measure the folding free energy at varying experimental conditions.
arxiv  

Platelet Transcriptome Heterogeneity: A Role for RNA Uptake in Vascular Health and Disease [PDF]

, 2017
As our understanding of the platelet’s systemic role continues to expand beyond hemostasis and thrombosis, interrogation of the platelet’s ability to affect diverse biological processes is required.
Clancy, Lauren R.
core   +1 more source