Reversible and Rapid Transfer-RNA Deactivation as a Mechanism of Translational Repression in Stress
PLoS Genetics, 2013 Stress-induced changes of gene expression are crucial for survival of eukaryotic cells. Regulation at the level of translation provides the necessary plasticity for immediate changes of cellular activities and protein levels.
Andreas Czech +4 more
semanticscholar +1 more source
Characterization of three proteins involved in polypeptide chain termination. [PDF]
, 1969 Journal ArticleAt each stage of elongation, the growing polypeptide chain is bound to the ribosome-messenger RNA complex through the transfer RNA of the most recently incorporated amino acid residue.
Capecchi, Mario R., Klein, Herbert A.
core
Genetics, 2013 Transfer RNAs (tRNAs) are essential for protein synthesis. In eukaryotes, tRNA biosynthesis employs a specialized RNA polymerase that generates initial transcripts that must be subsequently altered via a multitude of post-transcriptional steps before the
A. Hopper
semanticscholar +1 more source
Asymptotic Enumeration of RNA Structures with Pseudoknots [PDF]
arXiv, 2007 In this paper we present the asymptotic enumeration of RNA structures with pseudoknots. We develop a general framework for the computation of exponential growth rate and the sub exponential factors for $k$-noncrossing RNA structures. Our results are based on the generating function for the number of $k$-noncrossing RNA pseudoknot structures, ${\sf S}_k(
arxiv
Screening Genome Sequences for Known RNA Genes and Motifs [PDF]
, 2015 This methods paper presents computational protocols for the identification of non-coding RNA genes or RNA motifs within genomic sequences. An application to bacterial small RNA is proposed.
arxiv +1 more source
Predicting Cellular Responses to Novel Drug Perturbations at a Single-Cell Resolution [PDF]
arXiv, 2022 Single-cell transcriptomics enabled the study of cellular heterogeneity in response to perturbations at the resolution of individual cells. However, scaling high-throughput screens (HTSs) to measure cellular responses for many drugs remains a challenge due to technical limitations and, more importantly, the cost of such multiplexed experiments.
arxiv
Structurexplor : a platform for the exploration of structural features of RNA secondary structures [PDF]
, 2017 : Summary: Discovering function-related structural features, such as the cloverleaf shape of transfer RNA secondary structures, is essential to understand RNA function.
Glouzon, Jean-Pierre Séhi +2 more
core +1 more source
Structural organization of complexes of transfer RNAs with aminoacyl transfer RNA synthetases
Nucleic Acids Research, 1977 A variety of experimental data on synthetase-tRNA interactions are examined. Although these data previously had no direct explanation when viewed only in terms of the tRNA cloverleaf diagram, they can be rationalized according to a simple proposal that takes account of the three dimensional structure of tRNA.
Paul Schimmel, Alexander Rich
openaire +4 more sources
Transfer RNA modifications: nature's combinatorial chemistry playground
Wiley Interdisciplinary Reviews - RNA, 2013 Following synthesis, tRNAs are peppered by numerous chemical modifications which may differentially affect a tRNA's structure and function. Although modifications affecting the business ends of a tRNA are predictably important for cell viability, a ...
J. Jackman, J. Alfonzo
semanticscholar +1 more source
Small RNA-based feedforward loop with AND-gate logic regulates extrachromosomal DNA transfer in Salmonella [PDF]
, 2015 Horizontal gene transfer via plasmid conjugation is a major driving force in microbial evolution but constitutes a complex process that requires synchronization with the physiological state of the host bacteria.
Casadesús Pursals, Josep +3 more
core +1 more source