Results 71 to 80 of about 1,133,805 (266)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Construction of ICU patient transfer readiness scale and its reliability and validity test
Huli yanjiu, 2023 ObjectiveTo construct a ICU patient transfer readiness scale and test its reliability and validity.MethodsGuided by the Transition Theory and based on the Chinese version of The Hospital Readiness Scale， the entry pool was constructed based on relevant ...
CHEN Xueli +4 more
doaj
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
The effect of constant practice in transfer tests
Motriz: Revista de Educacao FisicaBACKGROUND There is aconsensus that repetition observed in constant practice producesminimalbenefits to the transfer of learning. OBJECTIVE The purpose of this study was to investigatein 3 experiments the effects of constant practicein transfer contexts.
Guilherme Menezes Lage +6 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
The Dynamic Prediction Method for Aircraft Cabin Temperatures Based on Flight Test Data
AerospaceFor advanced aircraft, the temperature environment inside the cabin is very severe due to the high flight speed and the compact concentration of the electronic equipment in the cabin.
He Li +5 more
doaj +1 more source
Advances in Mechanical Engineering, 2015 The axial heat transfer coefficient during flow boiling of n -hexane was measured using infrared thermography to determine the axial wall temperature in three geometrically similar annular gaps with different widths ( s = 1.5 mm, s = 1 mm, s = 0.5 mm).
Gunar Boye +2 more
doaj +1 more source
Clinics, 2015 OBJECTIVE: To determine whether Tai Chi Chuan or ballroom dancing promotes better performance with respect to postural balance, gait, and postural transfer among elderly people.
Miguel Antônio Rahal +6 more
doaj +1 more source