Results 91 to 100 of about 616,358 (307)

The bromodomain-containing protein Ibd1 links multiple chromatin related protein complexes to highly expressed genes in Tetrahymena thermophila

, 2018
Background: The chromatin remodelers of the SWI/SNF family are critical transcriptional regulators. Recognition of lysine acetylation through a bromodomain (BRD) component is key to SWI/SNF function; in most eukaryotes, this function is attributed to ...
Burtch, Alyson, Fillingham, Jeffrey, Garg, Jyoti, Gingras, Anne-Claude, Lambert, Jean-Philippe, Mudalige, Cristina Thuppu, Nabeel-Shah, Syed, Pearlman, Ronald E., Ponce, Marcelo, Saettone, Alejandro   +9 more
core   +1 more source

Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis

Advanced Science, EarlyView.
This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou, Yongfeng Chen, Longyou Xiao, Wei Qi, Tianshu Du, Qiang Sun, Borui Xue, Qinghe Zhao, Pengfei Xie, Zi Ye, Fei Han, Lingli Guo, Yang Jiao, Ranran Zhang, Hong Jia, Xiao Huang, Jianwei Guo, Peng Wang, Huayi Wang, Yuanrui Wang, Wenjing Chen, Haining Wu, Liumin He, Dawei Zhang   +23 more
wiley   +1 more source

Development and Preclinical Testing of a Novel Neurodenervant in the Rat: C3 Transferase Mitigates Botulinum Toxin’s Adverse Effects on Muscle Mechanics

Toxins
Spasticity, characterized by elevated muscle tone, is commonly managed with botulinum toxin type A (BTX-A). However, BTX-A can paradoxically increase passive muscle forces, narrow muscles’ length range of force exertion (lrange), and elevate ...
Cemre Su Kaya Keles, Zeynep D. Akdeniz Dogan, Can A. Yucesoy   +2 more
doaj   +1 more source

Glutation-S-transferase activity of loach embryos during embryogenesis under the action of sodium hypochlorite

Біологічні студії, 2016
he effect of sodium hypochlorite obtained at electrolysis of isotonic solution of sodium chloride that is a source of active oxygen on activity of glutation-s-transferase in loach embryos was studied.
N. P. Harasym, A. R. Zyn, A. O. Bezkorovayny, D. I. Sanagursky   +3 more
doaj   +1 more source

Biosynthesis of thiocarboxylic acid-containing natural products. [PDF]

, 2018
Thiocarboxylic acid-containing natural products are rare and their biosynthesis and biological significance remain unknown. Thioplatensimycin (thioPTM) and thioplatencin (thioPTN), thiocarboxylic acid congeners of the antibacterial natural products ...
Deng, Youchao, Dong, Liao-Bin, Duan, Yanwen, He, Cyndi Qixin, Houk, KN, Huang, Yong, Kang, Dingding, Rudolf, Jeffrey D, Shen, Ben, Wang, Nan   +9 more
core   +1 more source

Bifidobacterium Pseudolongum‐Derived Acetate Attenuates Acute Pancreatitis Through GPR43‐Mediated Suppression of M1 Macrophage Polarization

Advanced Science, EarlyView.
The severity of acute pancreatitis (AP) is linked to reduced abundance of Bifidobacterium pseudolongum (B. pseudolongum). Administration of B. pseudolongum or its key metabolite acetate alleviates pancreatic and systemic inflammation by suppressing M1 macrophage polarization.
Langyi Guan, Xueyang Li, Cong He, Pan Zheng, Yaoyu Zou, Qi Zhu, Xin Li, Jie Liang, Junmin Yang, Li Zhang, Yuman Ye, Jianhua Wan, Huajing Ke, Jianping Liu, Nonghua Lu, Nianshuang Li, Yin Zhu   +16 more
wiley   +1 more source

Serum Gamma-Glutamyl Transferase and C-Reactive Protein in Essential Hypertension

Medical Journal of Dr. D.Y. Patil Vidyapeeth
Background: Hypertension is known to be one of the major causes of the global burden of many diseases. It is proving to be a critical medical and public health issue. Previous studies have drawn inconsistent conclusions about the risk of hypertension and
Richa Awasthi, Priyanka T. Manger, Vivek Katiyar   +2 more
doaj   +1 more source

Modulation of Rab GTPase function by a protein phosphocholine transferase. [PDF]

, 2011
The intracellular pathogen Legionella pneumophila modulates the activity of host GTPases to direct the transport and assembly of the membrane-bound compartment in which it resides.
Arasaki, Kohei, Galán, Jorge E, Liu, Xiaoyun, McDonough, Justin, Mukherjee, Shaeri, Roy, Craig R   +5 more
core  

Proteome readjustments in the apoplastic space of Arabidopsis thaliana ggt1 mutant leaves exposed to UV-B radiation [PDF]

, 2015
Ultraviolet-B radiation acts as an environmental stimulus, but in high doses it has detrimental effects on plant metabolism. Plasma membranes represent a major target for ROS generated by this harmful radiation.
ARRIGONI, GIORGIO, FABREGA PRATS, MARTA, GIARETTA, SABRINA, Leonard Ebinezer Barnabas, MASI, ANTONIO, PIVATO, MICAELA, PRASAD, DINESH, Syed M. M. Mehdi, TRENTIN, ANNA RITA   +8 more
core   +2 more sources

Engineered Bacteria Factory Integrating Drug Delivery and Antibody Manufacture for Activating the STING Signal Pathway Mediated Tumor Immunotherapy

Advanced Science, EarlyView.
To address the limitations of protein‐based ICIs in applications, this study constructed an engineered bacterium, HRB, capable of expressing aCD47 in hypoxic TME. Through the Schiff base reaction, responsive liposomes (LC) loaded with the STING agonist cGAMP were connected to the surface of bacteria to form HRB@LC.
Peng‐Shuo Dong, Tian Yao, Yong Li, Zi‐Hui Yan, Xiao‐Ting Xie, Jia‐Hua Zou, Kai Cheng, Jin‐Xuan Fan, Yuan‐Di Zhao, Qiu‐Ran Xu   +9 more
wiley   +1 more source