Results 71 to 80 of about 100,115 (305)
Glutathione S-transferases in pediatric cancer
Frontiers in Oncology, 2011 The glutathione S-transferases (GSTs) are a family of ubiquitously-expressed polymorphic enzymes important for detoxifying endogenous and exogenous compounds.
Wen eLuo +3 more
doaj +1 more source
A population-based study of glutathione-S-transferase M1, T1 and P1 genotypes [PDF]
, 2008 A retrospective study on healthy, unrelated subjects was conducted in order to estimate population glutathione-S-transferases (GST) genotype frequencies in Slovak population of men and compare our results with already published data (GSEC project)^1^.
Duš +6 more
core +1 more source
Insights into enzymatic halogenation from computational studies [PDF]
, 2014 The halogenases are a group of enzymes that have only come to the fore over the last 10 years thanks to the discovery and characterization of several novel representatives.
Senn, Hans M.
core +2 more sources
Ovarian Matrisome Dynamics and αvβ3‐Mediated Regulation in Early Follicular Development
Advanced Science, EarlyView.The matrisome undergoes dynamic remodeling during early follicular development. Integrin αvβ3 mediates matrisome signals, regulating primordial follicle activation/atresia and secondary follicle growth via Hippo/mTOR pathways, with conserved roles in human ovaries, offering therapeutic targets for ovarian disorders.
Tong Wu +12 more
wiley +1 more source
Role of ethylene on various ripening pathways and on the development of sensory quality of Charentais cantaloupe melons [PDF]
, 2002 Charentais melons (Cucumis melo L., var cantalupensis Naud.) in which ethylene biosynthesis has been suppressed by an antisense ACC oxidase gene have been used to better understand the role of ethylene in the regulation of the ripening process of ...
Ambid, Christian +9 more
core +1 more source
A Bifunctional T3SS‐Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase
Advanced Science, EarlyView.Pathogenic bacteria exploit the metalloprotease effector NleD to subvert host defenses. Structural, biochemical, and infection analyses reveal a bifunctional mechanism by which NleD binds and inhibits the host phosphatase PPM1A while preserving its proteolytic activity against MAPKs.
Yaakov Socol +18 more
wiley +1 more source
The role of glutathione transferases in renal cell carcinoma [PDF]
Medicinski Podmladak, 2016 Mounting evidence suggest that members of the subfamily of cytosolic glutathione S-transferases (GSTs) possess roles far beyond the classical glutathione-dependent enzymatic conjugation of electrophilic metabolites and xenobiotics.
Ćorić Vesna +2 more
doaj +1 more source
Target RNAs strike back on MicroRNAs [PDF]
, 2018 MicroRNAs are extensively studied regulatory non-coding small RNAs that silence animal genes throughout most biological processes, typically doing so by binding to partially complementary sequences within target RNAs.
de la Mata, Manuel +3 more
core +1 more source
Advanced Science, EarlyView.By integrating single‐nuclei and spatial transcriptomics, this study presents a stereoscopic landscape of maize leaf to Puccinia polysora infection. Epidermal and mesophyll cells initiate primary defenses via RLPs/RLKs and jasmonic acid signaling. Cell‐cell communication analyses further reveal the underlying the dynamics of the underlying immune ...
Qiongqiong Wang +16 more
wiley +1 more source
Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Advanced Science, EarlyView.Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source