Results 61 to 70 of about 59,971 (301)
Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis
Advanced Science, EarlyView.Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang +16 more
wiley +1 more source
Introduction to a Special Issue on Disclosure and Concealment in Psychotherapy [PDF]
, 2016 Given that questions related to disclosure have long held the interest of both clinicians and researchers, we are excited to present this special issue of Counselling Psychology Quarterly focusing on disclosure and concealment in psychotherapy. All forms
Hill, Clara E, Knox, Sarah
core +1 more source
Divine madness: the dilemma of religious scruples in twentieth-century America and Britain [PDF]
, 2009 Religious scruples were a major problem within Roman Catholic circles until the late twentieth century. This article traces the shift from the cure of scruples being seen as the responsibility of religious advisers to them being labled an obsessional ...
Bourke, Joanna
core +1 more source
A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia
Advanced Science, EarlyView.A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun +11 more
wiley +1 more source
Actualidades Investigativas en Educación, 2009 En este trabajo, proponemos métodos para la ejecución y evaluación cuantitativa de ejercicios participativos en la enseñanza de las ciencias naturales, diseñados bajo los principios del constructivismo, trasladando el protagonismo de los profesores a ...
Marco V. Gutiérrez Soto +2 more
doaj +1 more source
A reescrita de Lady Macbeth por Leskov e os processos de adaptação e de apropriação [PDF]
, 2019 This article tries to provide a thorough analysis of Nikolai Leskov’s rewriting of Lady Macbeth, the Shakespearean character, in the novella Lady Macbeth of the Mtsensk District, from the perspective of Translation and Adaptation Studies.
Bellmunt Serrano, Manel
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Advanced Science, EarlyView.The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi +13 more
wiley +1 more source
Frontiers in Psychology, 2019 Friston’s (2010) free energy principle (FEP) offers an opportunity to rethink what is meant by the psychoanalytic concept of an object or discrete mental representation (Ogden, 1992). The significance of such objects in psychoanalysis is that they may be
Patrick Connolly
doaj +1 more source
Attitudes towards anorexia nervosa: Volitional stigma differences in a sample of pre-clinical medicine and psychology students [PDF]
, 2016 Background: Anorexia nervosa (AN) is a highly stigmatised condition, with treatment often involving multidisciplinary care. As such, understanding and comparing the attitudes of emerging mental health and medical professionals towards AN, within the ...
Bannatyne, Amy Jean +1 more
core +1 more source
Advanced Science, EarlyView.Using a novel zebrafish‐based inflammatory screening strategy, we screened and identified 18β‐glycyrrhetinic acid (18β‐GA) as a promising anti‐inflammatory candidate. We uncover a microglial mTOR–autophagy–NLRP3 axis that constitutes the mechanistic core of 18β‐GA–mediated neuroprotection.
Hua Gan +11 more
wiley +1 more source