Results 31 to 40 of about 165,649 (342)

Targeting transferrin receptors at the blood-brain barrier improves the uptake of immunoliposomes and subsequent cargo transport into the brain parenchyma

Scientific Reports, 2017
Drug delivery to the brain is hampered by the presence of the blood-brain barrier, which excludes most molecules from freely diffusing into the brain, and tightly regulates the active transport mechanisms that ensure sufficient delivery of nutrients to ...
K. B. Johnsen, A. Burkhart, Fredrik Melander, P. Kempen, Jonas Bruun Vejlebo, P. Siupka, M. Nielsen, T. Andresen, T. Moos   +8 more
semanticscholar   +1 more source

In Silico Tools for Analysis of Single-Nucleotide Polymorphisms in the Bovine Transferrin Gene

Animals, 2022
Dairy cattle with a high milk yield are susceptible to many infectious diseases, such as mastitis. Subclinical mastitis (SCM) is the most prevalent form of mastitis that predominantly affects animal health, and causes adverse effects on the quality and ...
Aarif Ali, Muneeb U. Rehman, Syed Mudasir Ahmad, Tabish Mehraj, Ishraq Hussain, Ahmed Nadeem, Manzoor Ur Rahman Mir, Showkat Ahmad Ganie   +7 more
doaj   +1 more source

Iron-deficiency and estrogen are associated with ischemic stroke by up-regulating transferrin to induce hypercoagulability

bioRxiv, 2019
In the accompanying manuscript, transferrin has been demonstrated to maintain coagulation balance by interacting with clotting factors, suggesting that elevated transferrin causes thromboembolic diseases and factors up-regulating transferrin is ...
Xiaopeng Tang, Mingqian Fang, Ruomei Cheng, Zhiye Zhang, Yuming Wang, Chuanbin Shen, Yajun Han, Qiumin Lu, Yingrong Du, Yingying Liu, Zhaohui Sun, Li-ping Zhu, James Mwangi, Min Xue, C. Long, R. Lai   +15 more
semanticscholar   +1 more source

Transferrin Receptor-Targeted Nanocarriers: Overcoming Barriers to Treat Glioblastoma

Pharmaceutics, 2022
Glioblastoma multiforme (GBM) is the most common and lethal type of brain tumor, and the clinically available approaches for its treatment are not curative.
Maria João Ramalho, Joana Angélica Loureiro, Manuel A. N. Coelho, Maria Carmo Pereira   +3 more
doaj   +1 more source

Transferrin plays a central role in coagulation balance by interacting with clotting factors

Cell Research, 2019
Coagulation balance is maintained through fine-tuned interactions among clotting factors, whose physiological concentrations vary substantially. In particular, the concentrations of coagulation proteases (pM to nM) are much lower than their natural ...
Xiaopeng Tang, Zhiye Zhang, Mingqian Fang, Yajun Han, Gan Wang, Sheng Wang, Min Xue, Yaxiong Li, Li Zhang, Jian Wu, Biqing Yang, James Mwangi, Qiumin Lu, Xiaoping Du, R. Lai   +14 more
semanticscholar   +1 more source

Dual Targeting of Cancer Cells and MMPs with Self-Assembly Hybrid Nanoparticles for Combination Therapy in Combating Cancer

Pharmaceutics, 2021
The co-delivery of chemotherapeutic agents and immune modulators to their targets remains to be a great challenge for nanocarriers. Here, we developed a hybrid thermosensitive nanoparticle (TMNP) which could co-deliver paclitaxel-loaded transferrin (PTX ...
Kai Zhang, Jingjing Li, Xiaofei Xin, Xiaoqing Du, Di Zhao, Chao Qin, Xiaopeng Han, Meirong Huo, Lei Yang, Lifang Yin   +9 more
doaj   +1 more source

Self-assembled IR780-loaded transferrin nanoparticles as an imaging, targeting and PDT/PTT agent for cancer therapy

Scientific Reports, 2016
Combination of photothermal and photodynamic therapy (PTT/PDT) offer unique advantages over PDT alone. However, to achieve synergetic PDT/PTT effect, one generally needs two lasers with different wavelengths.
Kaikai Wang, Yifan Zhang, Juan Wang, A. Yuan, Minjie Sun, Jinhui Wu, Yiqiao Hu   +6 more
semanticscholar   +1 more source

Transferrin and the transferrin cycle in Belgrade rat reticulocytes

Journal of Biological Chemistry, 1993
Belgrade rats have an autosomal recessive anemia with hypochromia and microcytosis. Iron uptake into reticulocytes is approximately 20% of normal, but transferrin uptake is unimpaired. We have systematically compared the transferrin cycle in Belgrade versus normal reticulocytes to locate the defect more precisely.
Michael D. Garrick, Laura M. Garrick, D. S. Cohan, Kathleen Gniecko, Yeheng Liu   +4 more
openaire   +3 more sources

Transferrin Saturation and Mortality [PDF]

Clinical Chemistry, 2011
To the Editor: Ellervik and colleagues (1) recently reported a positive association between transferrin saturation (TS) and mortality. Several questions arise from this observation: Is the association due to all causes of iron overload or to hereditary hemochromatosis only? Does the study underestimate the true association?
Benyamin, Beben, Montgomery, Grant W., Martin, Nicholas G., Whitfield, John B.   +3 more
openaire   +5 more sources

Transferrin Receptors TfR1 and TfR2 Bind Transferrin through Differing Mechanisms.

Biochemistry, 2018
Hereditary hemochromatosis (HH), a disease marked by chronic iron overload from insufficient expression of the hormone hepcidin, is one of the most common genetic diseases. One form of HH (type III) results from mutations in transferrin receptor-2 (TfR2).
M. Kleven, S. Jue, C. Enns
semanticscholar   +1 more source