Results 111 to 120 of about 133,411 (307)

Fungal iron availability during deep seated candidiasis is defined by a complex interplay involving systemic and local events [PDF]

, 2013
Peer reviewedPublisher ...
A Matusch, A Mencacci, AE Armitage, Alistair J. P. Brown, AM Thomson, Andrea Raab, AS Ibrahim, B Spellberg, BD Corbin, CH Park, CJ Barelle, CM Lloyd, CP Smith, D Kaloriti, D Suckau, Dagmar S. Urgast, David Stead, DD Haines, DH Navarathna, DM Barry, DM MacCallum, DM MacCallum, Donna M. MacCallum, DS Urgast, ED Weinberg, EE Johnson, EH Seeley, G Kovtunovych, GD Brown, GO Latunde-Dada, H Drakesmith, H Haas, H Wang, HI Feldman, IV Ene, JC Sardi, JF McManus, JM El HageChahine, Joanna Potrykus, Jörg Feldmann, M Ogawa, MC Lorenz, MD Maines, MI Hood, MJ Marakalala, ML Pendrak, N Ramanan, N Van Rooijen, NA Gow, Nico van Rooijen, P Heymann, Q Qian, R Santos, RJ Ward, RS Almeida, S Shimma, SA Knight, Scott G. Filler, T Roemer, W Fonzi, WH Jung   +60 more
core   +4 more sources

Additive‐Manufactured, Multifunctional Bioreactor Technology for Dynamic Culture of 3D Bioprinted Tissue Models

Advanced Materials Technologies, EarlyView.
We introduce an additively manufactured bioreactor with a perfusion flow system and integrated temperature and pH sensors for skeletal muscle tissue biofabrication. The bioreactor's performance was evaluated by assessing the viability, spreading of the myoblast cells in a printed scaffold, and contraction of the isolated murine musculi interossei ...
Lys Sprenger, Johann Schorzmann, Hsuan‐Heng Lu, Muhammad Osama, Julian Bauer, Michael Haug, Oliver Friedrich, Aldo R. Boccaccini, Frank Döpper, Sahar Salehi   +9 more
wiley   +1 more source

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

Ovarian Matrisome Dynamics and αvβ3‐Mediated Regulation in Early Follicular Development

Advanced Science, EarlyView.
The matrisome undergoes dynamic remodeling during early follicular development. Integrin αvβ3 mediates matrisome signals, regulating primordial follicle activation/atresia and secondary follicle growth via Hippo/mTOR pathways, with conserved roles in human ovaries, offering therapeutic targets for ovarian disorders.
Tong Wu, Yanzhi Feng, Qingqing Zhu, Ting Jiang, Yueyue Gao, Kebing Nie, Xianan Tang, Ying Chen, Dianxing Hu, Xudan Yang, Shixuan Wang, Meng Wu, Jinjin Zhang   +12 more
wiley   +1 more source

The significance of soluble transferrin receptors in diagnosing iron deficiency anemia

Romanian Journal of Laboratory Medicine, 2015
Introduction. In recent years, determination of soluble transferrin receptor levels has been emerging as a test that can reliably indicate iron deficiency in various states, and that is non-invasive and easy to use.
Tijanić Ivan, Vučić Miodrag, Mačukanović Golubović Lana   +2 more
doaj   +1 more source

Engineered ferritin for lanthanide binding [PDF]

, 2018
Ferritin H-homopolymers have been extensively used as nanocarriers for diverse applications in the targeted delivery of drugs and imaging agents, due to their unique ability to bind the transferrin receptor (CD71), highly overexpressed in most tumor ...
Baiocco, Paola, Benni, Irene, Białasek, Maciej, Boffi, Alberto, Bonamore, Alessandra, Calisti, Lorenzo, CARDOSO TRABUCO, Matilde, des Georges, Amédée, Ilari, Andrea, Krol, Magdalena, Montemiglio, LINDA CELESTE, Rygiel, Tomasz, Taciak, Bartłomiej, Testi, Claudia   +13 more
core   +2 more sources

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Dynamic regulation of the Trypanosoma brucei transferrin receptor in response to iron starvation is mediated via the 3'UTR.

PLoS ONE, 2018
The bloodstream form of the parasite Trypanosoma brucei obtains iron from its mammalian host by receptor-mediated endocytosis of host transferrin through its own unique transferrin receptor (TbTfR).
Corinna Benz, Winston Lo, Nadin Fathallah, Ashley Connor-Guscott, Henry J Benns, Michael D Urbaniak   +5 more
doaj   +1 more source

The use of inhibitors to study endocytic pathways of gene carriers: optimization and pitfalls [PDF]

, 2010
Nonviral gene complexes can enter mammalian cells through different endocytic pathways. For efficient optimization of the gene carrier it is important to profile its cellular uptake, because this largely determines its intracellular processing and ...
Dries Vercauteren, Roosmarijn E Vandenbroucke, Arwyn T Jones, Joanna Rejman, Joseph Demeester, Stefaan C De Smedt, Niek N Sanders, Kevin Braeckmans, Wattiaux, Conner, Jones, Grimmer, Rejman, Widera, Maxfield, Mayor, Simons, Parton, Pelkmans, Torgersen, Puri, Singh, Marks, Zuhorn, Glebov, Medina-Kauwe, Khalil, Elouahabi, Midoux, von Gersdorff, Douglas, Wong, Gabrielson, Banks, Ivanov, Wang, Larkin, Rodal, Parton, Nabi, Gonçalves, Nichols, Hinrichsen, Huang, Vanden Broeck, Benmerah, Payne, Damke, Liu, Lamaze, Rejman, Mano, Weyermann, Subtil, Huth, Davis, Yuwen, Sonnichsen   +57 more
core   +3 more sources

A 3D In Vitro Model of the Human Hepatobiliary Junction

Advanced Science, EarlyView.
A 3D human organoid platform reconstructs the hepatobiliary junction between primary adult hepatocytes and intrahepatic cholangiocytes. These adult hepatobiliary organoids (aHBOs) support directional bile transport from canaliculi to ductule‐like structures, enable quantitative imaging of junction dynamics, and reveal cell‐type‐specific vulnerabilities
Ashley D. Westerfield, Katarzyna A. Grzelak, Katie Katsuyama, Vardhman Kumar, Bess M. Miller, Joa Yun, Jesse Kirkpatrick, David Mankus, Margaret E. Bisher, Abigail K.R. Lytton‐Jean, Z. Gordon Jiang, David D. Lee, Christopher S. Chen, Sangeeta N. Bhatia   +13 more
wiley   +1 more source