Results 191 to 200 of about 1,263,349 (289)

Restoration of Extrinsic Grasp With Supinator to Flexor Digitorum Superficialis and Extensor Carpi Radialis Brevis to Anterior Interosseous Nerve Transfers for Medial Cord Injury of the Brachial Plexus. [PDF]

Plast Reconstr Surg Glob Open
Tadisina KK, Sharma K.
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Bilateral elbow joint osteonecrosis reconstructed by custom distal humerus hemiarthroplasty and megaprosthesis with tendon and nerve transfers - A case report. [PDF]

JPRAS Open
Hoftiezer YAJ, Werenski JO, Posada Alvarez C, Lee SG, Lozano-Calderón SA.   +4 more
europepmc   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Exploring determinants of cumulative live birth rates in IVF: insights from the EELI study in Lebanon. [PDF]

Reprod Health
Fares KS, Whaibeh ER, Matta EE, Atallah HB, Kaadi ES, Zeid LJA, Hammoud IH, El Hachem HS, Mrad MA, Tayeh GHA.   +9 more
europepmc   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Effect of combining lower- and higher-value monthly cash transfers with nutrition-sensitive agriculture, male engagement and psychosocial intervention on maternal depressive symptoms in rural Malawi: a secondary analysis of a cluster-randomised controlled trial. [PDF]

BMJ Glob Health
Bliznashka L, Nwabuikwu O, Ahun MN, Roschnik N, Phiri B, Gondwe-Matekesa E, Kachinjika M, Mvula P, Munthali A, Maggio D, Katundu M, Maleta K, Gladstone M, Gelli A, and the MAZIKO trial team.   +14 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Assessing the Impact of a Rapid Response Team on Code Blue Incidents and Hospital Mortality Rate: Evidence From a Tertiary Care Hospital in India. [PDF]

Cureus
Tom L, Pillai RR, Rajan G, Binub K.
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source