Results 181 to 190 of about 5,482,088 (343)

Evaluation of KRAS and NRAS mutations in metastatic colorectal cancer: an 8‐year study of 10 754 patients in Turkey

Molecular Oncology, EarlyView.
This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci, Izzet Akiva, Yavuz Hakan Ozon, Hakan Berkil, Huseyin Karadayi, Omer Dizdar, Suayib Yalcin   +6 more
wiley   +1 more source

Simultaneous multigene integration in Aspergillus fumigatus using CRISPR/Cas9 and endogenous counter-selectable markers. [PDF]

J Biol Eng
Sastré-Velásquez LE, Mach N, Mertens B, Kühbacher A, Merschak P, Dallemulle A, Lechner L, Baldin C, Diallinas G, Gsaller F.   +9 more
europepmc   +1 more source

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source

Lupins in the genome editing era: advances in plant cell culture, double haploid technology and genetic transformation for crop improvement. [PDF]

Front Plant Sci
Pathi KM, Sprink T.
europepmc   +1 more source

Agrobacterium-mediated in planta genetic transformation of sugarcane setts

Plant Cell Reports, 2015
S. Mayavan, K. Subramanyam, Balusamy Jaganath, D. Sathish, M. Manickavasagam, A. Ganapathi   +5 more
semanticscholar   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

Effective <i>Agrobacterium</i>-Mediated Transformation System for Eureka Lemon Using Whole Cotyledonary Node. [PDF]

Plants (Basel)
Zhao J, Chen Y, Wang J, Wang C, Zhou Y.
europepmc   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

Molecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song, Ting Liu, Qishan Hao, Qiuyun Fang, Xiaoyuan Gong, Yan Li, Zheng Tian, Hui Wei, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi   +11 more
wiley   +1 more source

Genetic Transformation of the Marine Oleaginous Microalga, Marinichlorella sp. NKG400014. [PDF]

Mar Biotechnol (NY)
Kumakubo R, Sagawa K, Tanaka T.
europepmc   +1 more source

Telomerase reverse transcriptase promoter mutation is an early somatic genetic alteration in the transformation of premalignant nodules in hepatocellular carcinoma on cirrhosis

Hepatology, 2014
J. Nault, J. Calderaro, L. di Tommaso, C. Balabaud, E. Zafrani, P. Bioulac-Sage, M. Roncalli, J. Zucman‐Rossi   +7 more
semanticscholar   +1 more source