Results 191 to 200 of about 5,003,580 (289)

The IFNγ‐CIITA‐MHC II axis modulates melanoma cell susceptibility to NK‐cell‐mediated cytotoxicity

Molecular Oncology, EarlyView.
Natural killer (NK) cells play a central role in anti‐melanoma immunity. However, melanoma cells adapt during co‐culture by upregulating CIITA and MHC II in response to interferon gamma (IFNγ), thereby evading NK‐cell lysis. Blocking IFNγ signaling or treatment with dimethyl fumarate/simvastatin counteracts this immune escape and maintains NK‐cell ...
Lena C. M. Krause, Rixa‐Mareike Köhn, Christian Ickes, Julia Lenger, Jonas Fischer, Sabrina Cappello, Ivan Bogeski   +6 more
wiley   +1 more source

Not just a by‐product: circular DNA molecules derived from V(D)J recombination are linked to worse prognosis in B‐cell leukemia

Molecular Oncology, EarlyView.
Gao et al. report that circular DNA molecules created as by‐products of V(D)J recombination during lymphocyte maturation (ESCs) can replicate and be retained for much longer than previously thought in healthy cells. In BCP‐ALL cells, increased ESC abundance correlates with a greater chance of relapse likely mediated by their ability to induce genome ...
Davide Pradella, Andrea Ventura
wiley   +1 more source

Development of chloroplast transformation for five species in the genus Nicotiana. [PDF]

Plant J
Luo Q, Obst S, Chang S, Ruf S, Bock R.
europepmc   +1 more source

Genetic transformation of mouse embryos by microinjection of purified DNA.

Proceedings of the National Academy of Sciences of the United States of America, 1980
J. Gordon, G. Scangos, D. J. Plotkin, J. Barbosa, F. Ruddle   +4 more
semanticscholar   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Large-scale screening of genes responsible for silique length and seed size in Brassica Napus via pooled CRISPR library. [PDF]

BMC Genomics
Zhao C, Xia J, Liang B, Lin S, Song Y, Hong D, Gu J.   +6 more
europepmc   +1 more source

High aspect ratio nanomaterials enable delivery of functional genetic material without DNA integration in mature plants

bioRxiv, 2017
Gozde S. Demirer, Huan Zhang, Juliana L. Matos, Natalie S. Goh, Francis J. Cunningham, Younghun Sung, Roger L. Chang, Abhishek J. Aditham, Linda Chio, M. Cho, B. Staskawicz, M. Landry   +11 more
semanticscholar   +1 more source

Experiment in Genetic Transformation

The American Biology Teacher, 1975
openaire   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Morphogenetic Factors as a Tool for Enhancing Plant Regeneration Capacity During In Vitro Transformation. [PDF]

Int J Mol Sci
Bakulin SD, Monakhos SG, Bruskin SA.
europepmc   +1 more source