Results 231 to 240 of about 1,026,560 (278)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

CRISPR-induced knockouts reveal a dual role for the soybean NFR5α gene in symbiotic nitrogen fixation and root hair development. [PDF]

Plant Genome
Niazian M, de Ronne M, Beauchamp CJ, Belzile F, Torkamaneh D.   +4 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Dysbiosis-Mediated Regulation of Stem Cells the First Hit for Cancer Generation. [PDF]

Int J Mol Sci
Gargiulo-Isacco C, Pham VH, Nguyen KCD, Tran TC, Aityan SK, Del Prete R, Jirillo E, Santacroce L.   +7 more
europepmc   +1 more source

From Inflammation to Malignancy: The Link Between Endometriosis and Gynecological Cancers. [PDF]

Int J Mol Sci
Kłodnicka K, Michalska A, Januszewski J, Forma A, Teresiński G, Flieger J, Bogucki J, Maciejewski M, Syty K, Baj J.   +9 more
europepmc   +1 more source

Signaling pathways and targeted interventions for precancers. [PDF]

Signal Transduct Target Ther
Yang J, Wang S, Li X, Xu H, Sun T, Hu T, Luo J, Zhou H.   +7 more
europepmc   +1 more source

Genomic Insights and Bioconversion Potential in the Black Soldier Fly (<i>Hermetia illucens</i>): Current Advances and Future Directions. [PDF]

Insects
Oliveira J, Guilgur LG, Assunção R, Murta D, Trindade A.   +4 more
europepmc   +1 more source

Fifty Years and Counting: Searching for the "Silver Bullet" or the "Silver Shotgun" to Mitigate Preharvest Aflatoxin Contamination. [PDF]

Toxins (Basel)
Guo B, Foka ICK, Wu D, Clevenger JP, Di R, Fountain JC.   +5 more
europepmc   +1 more source

Retinocytoma: Clinical and Genetic Characteristics in 16 Pediatric and Adult Cases. [PDF]

Ocul Oncol Pathol
Widehen C, Cassoux N, Malaise D, Aerts I, Doz F, Gauthier-Villars M, Matet A, Lumbroso-Le Rouic L.   +7 more
europepmc   +1 more source