Results 121 to 130 of about 1,241,486 (266)

Building Health Policy and Systems Research (HPSR) capacity in India: Reflections from the India HPSR fellowship program (2020–2023)

Health Research Policy and Systems
Building capacity for Health Policy and Systems Research (HPSR) is critical for advancing the field in lower- and middle-income countries (LMICs). The India HPSR fellowship program is a home-grown capacity-building initiative, anchored at the Health ...
Shilpa John, Sudha Ramani, Syed Mohd Abbas, Sumit Kane, Dorothy Lall, Prashanth N. Srinivas, Devaki Nambiar, Bruno Marchal, Sara Van Belle, Rajeev Sadanandan, Narayanan Devadasan   +10 more
doaj   +1 more source

TAAT technology toolkits and their strategic delopyment: Clearinghouse technical report series 001

, 2023
The African Development Bank recently launched Feed Africa: A Strategy for Agricultural Transformation in Africa. This loan program is intended to unlock Africa’s agricultural potential and boost job creation with a view to diversifying African economies
Technologies for African Agricultural Transformation
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

High-throughput dataset of impurity adsorption on common catalysts in biomass upgrading applications

Scientific Data
An extensive dataset consisting of adsorption energies of pernicious impurities present in biomass upgrading processes on common catalysts and support materials has been generated.
Michelle A. Nolen, Sean A. Tacey, Martha A. Arellano-Treviño, Kurt M. Van Allsburg, Carrie A. Farberow   +4 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

The cost of heart failure in Australia: a linked primary and secondary care analysis

BMC Health Services Research
Background Heart failure (HF) places a substantial and rising burden on Australia’s health system. Existing cost estimates are outdated and based on modelling rather than real-world data.
Sean Randall, Sangita Shakya, Madison Frith, Crystal Man Ying Lee, Bernard Asiamah-Asare, Kevin Eng Kwong Chai, Lan Gao, Richard Varhol, James Boyd, Suzanne Robinson   +9 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

The role of alcohol consumption in the lives of older Australian women: qualitative insights and an agenda for further research, policy and practice

BMC Public Health
Background Alcohol consumption presents a threat to the health and wellbeing of women. The alcohol industry often pushes back at global efforts to prioritise the prevention of alcohol harms to women.
Simone McCarthy, Hannah Pitt, Kelli Benjamin, Julia Stafford, Danica Keric, Grace Arnot, Samantha Thomas   +6 more
doaj   +1 more source

A multimodal GeoAI approach to combining text with spatiotemporal features for enhanced relevance classification of social media posts in disaster response

Big Earth Data
Geo-referenced social media data supports disaster management by offering real-time insights through user-generated content. To identify critical information amid high volumes of noise, classifying the relevance of posts is essential.
David Hanny, Sebastian Schmidt, Shaily Gandhi, Michael Granitzer, Bernd Resch   +4 more
doaj   +1 more source