Results 151 to 160 of about 6,507,008 (334)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Expression of folate receptors and heterogeneous nuclear ribonucleoprotein E1 in women with human papillomavirus mediated transformation of cervical tissue to cancer [PDF]

, 2003
M. Radhakrishna Pillai
openalex   +1 more source

Calibration chain transformation improves the comparability of organic hydrogen and oxygen stable isotope data [PDF]

, 2021
Sarah Magozzi, Clément P. Bataille, Keith A. Hobson, Michael B. Wunder, John D. Howa, Andrea Contina, Hannah B. Vander Zanden, Gabriel J. Bowen   +7 more
openalex   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

“It’s changing our lives, not for the better. It’s important that we have a say”. The role of young people in informing public health and policy decisions about gambling marketing

BMC Public Health
Background Marketing has a significant impact on the normalisation of gambling for youth across the globe. This has included shaping positive attitudes towards gambling, as well as increasing the social and cultural acceptance of gambling – particularly ...
Hannah Pitt, Simone McCarthy, Melanie Randle, Grace Arnot, Mike Daube, Samantha Thomas   +5 more
doaj   +1 more source

A general spectral transformation simultaneously including a Fourier transformation and a Laplace transformation [PDF]

A general spectral transformation is proposed and described. Its spectrum can be interpreted as a Fourier spectrum or a Laplace spectrum. The laws and functions of the method are discussed in comparison with the known transformations, and a sample ...
Marko, H.
core   +1 more source

Hepatic zonation of carbon and nitrogen fluxes derived from glutamine and ammonia transformations [PDF]

, 2010
Jurandir Fernando Comar, Fumie Suzuki‐Kemmelmeier, Jorgete Constantin, Adelar Bracht   +3 more
openalex   +1 more source

UV/ozone induced physicochemical transformations of polystyrene nanoparticles and their aggregation tendency and kinetics with natural organic matter in aqueous systems

, 2022
Xing Li, Sitong Ji, Erkai He, Willie J.G.M. Peijnenburg, Xinde Cao, Ling Zhao, Xiaoyun Xu, Peihua Zhang, Hao Qiu   +8 more
openalex   +2 more sources

o‐Quinodimethane Atropisomers: Enantioselective Synthesis and Stereospecific Transformation [PDF]

, 2022
Jianyang Dong, Andreas Ostertag, Christof Sparr   +2 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source