Results 151 to 160 of about 6,636,483 (334)

Transformations debugging transformations

open access: yes, 2017
Abstract: Practical model transformation (MT) frameworks are usually composed of multiple execution contexts, building an overall workflow by abstracting different aspects of execution. This heterogeneity brings additional challenges to debugging, which must address a combination of quite different graphical and textual formalisms.
Jukks, Maris   +2 more
openaire   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

open access: yesMolecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern   +7 more
wiley   +1 more source

“It’s changing our lives, not for the better. It’s important that we have a say”. The role of young people in informing public health and policy decisions about gambling marketing

open access: yesBMC Public Health
Background Marketing has a significant impact on the normalisation of gambling for youth across the globe. This has included shaping positive attitudes towards gambling, as well as increasing the social and cultural acceptance of gambling – particularly ...
Hannah Pitt   +5 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

A general spectral transformation simultaneously including a Fourier transformation and a Laplace transformation [PDF]

open access: yes
A general spectral transformation is proposed and described. Its spectrum can be interpreted as a Fourier spectrum or a Laplace spectrum. The laws and functions of the method are discussed in comparison with the known transformations, and a sample ...
Marko, H.
core   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser   +14 more
wiley   +1 more source

“Older people will die of old age. I’ll die of climate change”: engaging children and young people in climate decision making for public health

open access: yesBMC Public Health
Background The climate crisis is a significant risk to the health and wellbeing of children, young people, and future generations. While there are calls for children and young people’s engagement in climate decision making, current power structures limit
Grace Arnot   +4 more
doaj   +1 more source

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