Results 271 to 280 of about 6,507,008 (334)

Professional Education as Transformation [PDF]

, 2011
Deahl, Robert
core   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Composition Dependent Dynamic Behaviors of Non-Stoichiometric Cocrystalline Hydrogen-Bonded Organic Frameworks. [PDF]

Small
Hashimoto T, Oketani R, Hisaki I.
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Perceived clinical and ethical impact of digital transformation in healthcare and research: A survey in the MENA region. [PDF]

PLoS One
Hasan HE, Alzoubi KH, Khabour OF, Al-Delaimy WK, Goodman KW.   +4 more
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Developmental regulatory genes in recalcitrant forest trees: advances in somatic regeneration and genetic transformation. [PDF]

Front Plant Sci
Wang Y, Wang JH, Guo PR, Peng J, Xie CZ, Shi YD, Wu YH, Liao DZ, Sheng S.   +8 more
europepmc   +1 more source

The S-transform and the ideal transform

Journal of Algebra, 1979
openaire   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

<i>Fusarium pseudonygamai</i> Promotes Blastospore Transformation in <i>Ophiocordyceps sinensis</i>: Insights into Microbial Interaction and Key Mechanisms. [PDF]

J Fungi (Basel)
Khalid MZ, Zheng X, Han R, Cao L.
europepmc   +1 more source